Physiological Significance of NADPH
What are the physiological roles of NADPH produced in the Pentose Phosphate Pathway?
Vital for fatty acid synthesis, cholesterol synthesis, and detoxification reactions.
What are the key products of the oxidative phase of the Pentose Phosphate Pathway?
Two molecules of NADPH and ribulose-5-phosphate.
Importance of Ribose-5-Phosphate
What is the significance of Ribose-5-Phosphate in cellular metabolism?
It is crucial for nucleotide and nucleic acid synthesis.
Key Enzymes in the Pentose Phosphate Pathway
Which enzymes are involved in the non-oxidative phase of the Pentose Phosphate Pathway?
Phosphopentose Isomerase, Transketolase, and Transaldolase.
Functions of the Pentose Phosphate Pathway
What are the two primary functions of the Pentose Phosphate Pathway (PPP)?
Production of NADPH and synthesis of Ribose-5-Phosphate.
Key Enzymes in the Pentose Phosphate Pathway
What is the role of Glucose-6-Phosphate Dehydrogenase (G6PD) in the oxidative phase of PPP?
It converts glucose-6-phosphate to 6-phosphoglucono-δ-lactone, producing NADPH.
Regulation of the Pentose Phosphate Pathway
How is the Pentose Phosphate Pathway regulated?
Primarily by Glucose-6-Phosphate Dehydrogenase (G6PD), which is activated by NADP⁺ and inhibited by NADPH.
Clinical Relevance of G6PD Deficiency
What is G6PD deficiency and its clinical relevance?
A genetic disorder leading to hemolytic anemia due to impaired NADPH production and increased susceptibility to oxidative stress.
