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Which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK signaling?
STAT
Does TGF-β treatment cause cells to grow more or less in the soft-agar assay?

More

1/15
p.2
Kinase Linked Receptors

Which protein ultimately is translocated from the cytoplasm to the nucleus as a result of JAK signaling?

STAT

p.3
Effects of TGF-β on Cell Growth

Does TGF-β treatment cause cells to grow more or less in the soft-agar assay?

<p>More</p>

p.2
G-Protien Coupled Receptors

Is it more likely for a G-protein coupled receptor agonist to bind near the N- or C- terminus of the receptor?

N-terminus

p.4
SMADs

How many DNA binding domains do Smads have?

<p>1</p>

p.4
Effects of TGF-β on Cell Growth

Would it likely be most beneficial (for the tumor) for an early tumor to up- or down-regulate the TGF-β pathway?

Down-regulate

p.1
Nuclear Receptors

Which type of receptor would it take the longest to see the effects of your drug at the cellular level?

Nuclear receptors

p.3
TGF Beta Signaling Pathway

In the TGF-β pathway, which protein becomes activated first upon binding of a ligand?

TGFβR2

p.2
Nuclear Receptors

Where, in relation to the protein-coding region of a gene, are the binding sites that become occupied by nuclear receptors?

Upstream

p.3
TGF-B Signaling

The latent TBF-β peptide must be cleaved by what protease in order to be activated?

Plasmin

p.1
G-Protien Coupled Receptors

Which type of receptor most often utilizes second-messenger systems in its signaling?

G-protein coupled receptors

p.4
Effects of TGF-β on Cell Growth

Would it likely be most beneficial (for the tumor) for a large, well-developed tumor to up- or down-regulate the TGF-β pathway?

Up-regulate

p.1
Nuclear Receptors

For which type of receptor would having adequate membrane permeability of an agonist be most critical?

Nuclear receptors

p.3
TGF Beta Signaling Pathway

The levels of which second-messenger would be expected to increase following administration of nitroglycerin?

cGMP

p.2
G-Protien Coupled Receptors

Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or GDP?

GTP

p.4
SMADs

Different Smad complexes bind different genes. Which group of Smads is responsible for this specificity?

R-Smads

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