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Drug Absorption Mechanisms
What type of drugs are absorbed in the stomach?
Non-ionized, non-polar, lipid-soluble drugs.
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Controlled Medication Dynamics
What factors affect sustained release of medications?
Interaction with body fluid, Medium pH, Enzymatic activity.
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Volume of Distribution Factors
How does obesity affect lipid-soluble drugs?
It increases the volume of distribution.
What characterizes first-order kinetics?
<p>Rate is directly proportional to the concentration (linear)</p>
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Blood-Brain Barrier Penetration
What characteristics allow drugs to cross the Blood-Brain Barrier?
Unionized and lipophilic properties.
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Volume of Distribution Factors
What is the effect of volume of distribution?
It is influenced by solubility, protein binding, and molecular weight.
What is a key feature of zero-order kinetics?
<p>Rate is independent of the concentration (non-linear).</p>
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Drug Distribution Compartments
What is the excretion pathway for drugs with molecular weight > 500?
They will be excreted in the biliary system.
Which medications are examples of zero-order kinetics?
Warfarin, Alcohol, Aspirin, Theophylline, Tolbutamide, Phenytoin.
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Placental Drug Transfer
What factors allow drugs to cross the placenta?
Molecular weight < 500, lipophilic, and non-ionized.
