What is the follow-up procedure for asymptomatic AML up to 4 cm?
Imaging follow-up at 6-12 months.
What is renal lymphoma?
A type of malignant uncommon renal tumor.
1/112
p.3
Benign Renal Tumors

What is the follow-up procedure for asymptomatic AML up to 4 cm?

Imaging follow-up at 6-12 months.

p.15
Malignant Uncommon Renal Tumors

What is renal lymphoma?

A type of malignant uncommon renal tumor.

p.7
Clinical Manifestations of RCC

What are common symptoms of renal tumors?

Flank pain, hematuria, weight loss, fever, and night sweats.

p.18
Treatment Options for RCC

What is metastasectomy and when is it considered?

It is considered in select patients with solitary or limited metastases.

p.2
Renal Cell Carcinoma (RCC)

What is Wunderlich's syndrome?

Massive retroperitoneal hemorrhage from AML, seen in 10% of patients.

p.2
Renal Cell Carcinoma (RCC)

What is the most significant complication of AML?

Massive retroperitoneal hemorrhage (Wunderlich's syndrome).

p.7
Clinical Manifestations of RCC

What does the presence of the classic triad signify?

Advanced disease.

p.1
Benign Renal Tumors

What are some other types of benign renal tumors?

Renal leiomyoma, fibroma, lipoma, hemangioma, and reninoma.

p.4
Malignant Uncommon Renal Tumors

What percentage of all renal tumors do tumors of the renal pelvis account for?

Approximately 8%.

p.15
Malignant Uncommon Renal Tumors

What are sarcomas of the kidney?

A type of malignant uncommon renal tumor.

p.18
Treatment Options for RCC

What is the response rate for immunotherapy in treating metastatic disease?

13-15%.

p.10
Imaging Studies for Renal Masses

What is the value of fine-needle aspiration or biopsy in evaluating renal masses?

It has limited value.

p.7
Clinical Manifestations of RCC

What signs may indicate the presence of renal tumors?

Flank mass, hypertension, varicocele, and paraneoplastic syndrome.

p.13
Staging of Renal Tumors

What does T3a indicate in tumor staging?

Tumor invades the adrenal gland or perinephric fat but not beyond Gerota's fascia.

p.9
Paraneoplastic Syndromes Associated with RCC

What happens to paraneoplastic syndromes after tumor resection?

They are reversible.

p.7
Clinical Manifestations of RCC

Why is the classic triad of renal tumors now rare?

Because tumors are often detected incidentally at a low stage.

p.9
Paraneoplastic Syndromes Associated with RCC

What causes hypertension in RCC patients with paraneoplastic syndrome?

Increased renin.

p.11
Renal Cell Carcinoma (RCC)

Why might a biopsy be necessary for renal cell carcinoma (RCC)?

To differentiate RCC from metastatic malignant disease or renal lymphoma.

p.4
Risk Factors for RCC

Who is at risk for developing ureteral and renal pelvic tumors?

Patients with multiple, recurrent non-muscle invasive urothelial carcinoma (NMIUC) of the urinary bladder.

p.10
Imaging Studies for Renal Masses

What is the purpose of an abdominal ultrasound in imaging studies?

To differentiate solid tissue from cystic lesions.

p.17
Risk Factors for RCC

What is a risk associated with radical nephrectomy (RN)?

High risk of dialysis.

p.15
Malignant Uncommon Renal Tumors

From what does Wilms tumor develop?

From remnants of true immature kidney.

p.18
Treatment Options for RCC

When is radiotherapy primarily used in the treatment of metastatic disease?

As adjuvant treatment after radical nephrectomy and for metastatic lesions.

p.13
Staging of Renal Tumors

What does T2 indicate in tumor staging?

Tumor is greater than 7 cm and confined to the kidney.

p.7
Clinical Manifestations of RCC

What physical examination finding may indicate renal tumors?

A mass in the flank.

p.7
Staging of Renal Tumors

What is the most common site of metastasis for renal tumors?

Lung.

p.7
Clinical Manifestations of RCC

What is the classic triad of renal tumors?

Flank mass, hematuria, and pain.

p.1
Benign Renal Tumors

What is an oncocytoma?

A light brown homogeneous mass with no true capsule, often with a central scar on CT scan.

p.9
Paraneoplastic Syndromes Associated with RCC

What causes hypercalcemia in RCC patients?

Release of PTH-like substance or osteolytic metastasis to the bone.

p.8
Clinical Manifestations of RCC

What percentage of patients show positive hematuria in urinalysis?

60%.

p.17
Treatment Options for RCC

What is the gold standard for curative treatment of localized RCC?

Radical nephrectomy.

p.8
Clinical Manifestations of RCC

What type of anemia is commonly seen in RCC patients?

Normocytic anemia, usually not related to blood loss.

p.1
Benign Renal Tumors

What is the shape and outline of a simple renal cyst?

Round or oval in shape with a smooth outline and no internal echoes, septations, calcifications, thick wall, or irregular margins.

p.12
Staging of Renal Tumors

What are the common sites for blood spread in RCC?

Lung, liver, and bone.

p.5
Risk Factors for RCC

Name a few acquired risk factors for RCC.

Tobacco use, asbestos exposure, heavy metal exposure, analgesic phenacetin abuse, renal transplantation, renal cystic disease from dialysis, long-standing obesity, western diet.

p.12
Staging of Renal Tumors

What are the most common metastatic sites for RCC?

Lung, bone (most commonly spine), regional lymph nodes, liver, adrenal gland, contralateral kidney, and brain.

p.9
Paraneoplastic Syndromes Associated with RCC

What is a common symptom of paraneoplastic syndrome related to RCC?

Fever.

p.9
Paraneoplastic Syndromes Associated with RCC

What lab finding may be elevated in RCC patients with paraneoplastic syndrome?

Elevated alkaline phosphatase.

p.8
Clinical Manifestations of RCC

What are the typical results of urine culture and cytology in RCC patients?

Usually normal.

p.15
Malignant Uncommon Renal Tumors

What are metastatic tumors in the context of renal tumors?

Tumors that spread to the kidney from other parts of the body.

p.18
Treatment Options for RCC

In what situations is nephrectomy indicated?

In palliation for severe bleeding, pain, or paraneoplastic symptoms.

p.5
Clinical Manifestations of RCC

What is the mean age at presentation for RCC?

58 years.

p.13
Staging of Renal Tumors

What does T3c indicate in tumor staging?

Tumor extends into the vena cava above the diaphragm.

p.1
Benign Renal Tumors

How are renal cortical adenomas managed?

By wedge resection or other ablative therapies.

p.1
Benign Renal Tumors

How is an oncocytoma managed?

By partial nephrectomy.

p.11
Renal Cell Carcinoma (RCC)

What is a potential complication of needle puncture in renal tumors?

Spread of the tumor.

p.16
Treatment Options for RCC

What is the recommended primary treatment for localized RCC in surgical candidates?

Surgical excision.

p.18
Treatment Options for RCC

What is the overall response rate for chemotherapy in metastatic disease?

6%.

p.17
Treatment Options for RCC

What are thermal ablative therapies indicated for?

Local recurrence after previous NSS and hereditary renal cancers with multifocal lesions.

p.2
Renal Cell Carcinoma (RCC)

What percentage of AML cases are found in patients with Tuberous Sclerosis?

Approximately 20-30%.

p.6
Renal Cell Carcinoma (RCC)

What percentage of renal cell carcinoma cases are conventional or clear cell (ccRCC)?

70-80%.

p.5
Clinical Manifestations of RCC

At what age do patients with von-Hippel-Lindau (VHL) syndrome typically present with RCC?

Younger than 50 years.

p.5
Risk Factors for RCC

What are some hereditary risk factors for RCC?

Polycystic kidney disease, VHL syndrome, tuberous sclerosis, positive family history.

p.9
Paraneoplastic Syndromes Associated with RCC

What condition can lead to polycythemia in RCC patients?

Increased erythropoietin.

p.4
Malignant Uncommon Renal Tumors

What percentage of all urothelial tumors are renal pelvis tumors?

Less than 5%.

p.8
Paraneoplastic Syndromes Associated with RCC

What laboratory signs may indicate paraneoplastic syndrome?

Hypercalcemia, elevated LFTs, or erythrocytosis.

p.10
Imaging Studies for Renal Masses

When is MRI used in renal imaging?

For patients with allergy to intravenous contrast, renal insufficiency, or for evaluation and staging of IVC tumor thrombus.

p.5
Renal Cell Carcinoma (RCC)

What is the most common renal malignancy?

Renal cell carcinoma (RCC).

p.13
Staging of Renal Tumors

What does T1a indicate in tumor staging?

Tumor is less than 4 cm and confined to the kidney.

p.5
Risk Factors for RCC

Which gender is more commonly affected by RCC?

Males are affected twice as commonly as females.

p.1
Benign Renal Tumors

When is a simple renal cyst managed?

Only if symptomatic.

p.9
Paraneoplastic Syndromes Associated with RCC

What indicates a poor prognosis in RCC patients regarding paraneoplastic syndrome?

If the syndrome persists after tumor resection, metastasis is likely present.

p.9
Paraneoplastic Syndromes Associated with RCC

What is cachexia in the context of RCC?

Weight loss associated with paraneoplastic syndrome.

p.1
Benign Renal Tumors

What are the management options for symptomatic large angiomyolipomas?

Selective embolization, partial nephrectomy, or total nephrectomy.

p.11
Renal Cell Carcinoma (RCC)

What patient conditions may necessitate a biopsy for RCC?

Extensive comorbid disease or other contraindications to surgery.

p.16
Treatment Options for RCC

When is active surveillance indicated for RCC patients?

For patients with limited life expectancy or those who are unfit for or do not desire intervention.

p.10
Imaging Studies for Renal Masses

What can a renal CT scan detect?

Renal mass, extension into perinephric fat, enlarged lymph nodes, and other visceral lesions.

p.7
Clinical Manifestations of RCC

What percentage of renal tumors are found incidentally during evaluations for unrelated medical issues?

50%.

p.13
Staging of Renal Tumors

What does T1b indicate in tumor staging?

Tumor is between 4-7 cm and confined to the kidney.

p.7
Paraneoplastic Syndromes Associated with RCC

What is Stauffer's syndrome associated with renal tumors?

Hypercalcemia, polycythemia, hypertension, or nonmetastatic hepatic dysfunction.

p.6
Renal Cell Carcinoma (RCC)

What percentage of renal cell carcinoma cases are chromophobe (chRCC)?

3-5%.

p.6
Renal Cell Carcinoma (RCC)

What type of carcinoma is renal medullary carcinoma classified as?

A rare type of renal cell carcinoma.

p.9
Paraneoplastic Syndromes Associated with RCC

What blood condition can occur as a paraneoplastic syndrome in RCC?

Anemia.

p.11
Renal Cell Carcinoma (RCC)

What is a risk associated with invasive studies of renal masses?

Perirenal bleeding.

p.16
Treatment Options for RCC

What is the risk of active surveillance lowest?

When the renal mass is less than 3 cm.

p.8
Clinical Manifestations of RCC

What percentage of RCC patients experience anemia?

30%.

p.10
Imaging Studies for Renal Masses

What imaging studies are used for patients with pulmonary metastasis?

Chest radiography and chest CT scan.

p.17
Treatment Options for RCC

What types of thermal ablative therapies are mentioned?

Cryoablation and laser coagulation.

p.2
Renal Cell Carcinoma (RCC)

What is Tuberous Sclerosis?

A rare multi-system genetic disease that causes benign tumors to grow in various organs.

p.6
Renal Cell Carcinoma (RCC)

What percentage of renal cell carcinoma cases are papillary (chromophilic) (pRCC)?

10-15%.

p.1
Benign Renal Tumors

What are the management options for a symptomatic simple renal cyst?

Aspiration with sclerosing agent injection, unroofing cyst if it causes obstruction or hypertension, and surgical excision.

p.1
Benign Renal Tumors

What are renal cortical adenomas?

Small solid cortical lesions.

p.12
Paraneoplastic Syndromes Associated with RCC

What laboratory findings may indicate paraneoplastic syndrome or metastatic disease in RCC?

Elevated alkaline phosphatase, calcium, or liver function tests (LFTs).

p.11
Renal Cell Carcinoma (RCC)

In what scenario is establishing a pathological diagnosis of RCC crucial?

In patients with disseminated metastases or unresectable primary tumors.

p.16
Treatment Options for RCC

What is the only therapy for RCC that provides long-term follow-up?

Surgical excision.

p.3
Benign Renal Tumors

What is the treatment for large AML lesions or life-threatening hemorrhage?

Total nephrectomy.

p.15
Malignant Uncommon Renal Tumors

What is Wilms tumor?

The most common primary malignant renal tumor of childhood.

p.6
Renal Cell Carcinoma (RCC)

What is the gross appearance of the tumor in pathology?

Yellow or brown tumor with fibrotic, necrotic, or hemorrhagic areas.

p.12
Staging of Renal Tumors

What is local spread in renal cell carcinoma (RCC)?

Invasion to the collecting system, renal capsule, or involvement of the inferior vena cava (IVC), with spread to adjacent organs limited by Gerota's fascia.

p.9
Paraneoplastic Syndromes Associated with RCC

What percentage of patients with RCC experience paraneoplastic syndrome?

Approximately 20-30%.

p.2
Imaging Studies for Renal Masses

What does the presence of fat within a renal lesion indicate on a CT scan?

Excludes the diagnosis of RCC and is considered diagnostic of AML.

p.12
Paraneoplastic Syndromes Associated with RCC

What does persistence of paraneoplastic syndrome after nephrectomy indicate?

Unrecognized or micrometastatic disease.

p.9
Paraneoplastic Syndromes Associated with RCC

What is Stauffer's syndrome?

A reversible hepatitis associated with RCC that has not metastasized to the liver.

p.3
Benign Renal Tumors

What is the required intervention for symptomatic AML or AML greater than 4 cm?

Intervention is required, such as NSS or selective embolization.

p.8
Clinical Manifestations of RCC

What percentage of patients have an elevated ESR?

Up to 70%.

p.18
Treatment Options for RCC

Why is RCC considered a chemo-resistant tumor?

Because of its low overall response rate to chemotherapy.

p.5
Renal Cell Carcinoma (RCC)

What percentage of all primary malignant renal tumors is RCC responsible for?

Approximately 85%.

p.2
Renal Cell Carcinoma (RCC)

How does AML present in patients with Tuberous Sclerosis?

More likely to be bilateral and multicentric, with accelerated growth rate and symptomatic presentation.

p.13
Staging of Renal Tumors

What does T3b indicate in tumor staging?

Tumor extends into the renal vein or vena cava below the diaphragm.

p.12
Staging of Renal Tumors

How do metastases occur in RCC?

By lymphatic and hematogenous spread with equal frequency.

p.13
Staging of Renal Tumors

What does T4 indicate in tumor staging?

Tumor invades beyond Gerota's fascia.

p.1
Benign Renal Tumors

What is the angiographic appearance of vessels in an oncocytoma?

Often a spoke-wheel appearance.

p.11
Renal Cell Carcinoma (RCC)

What is a common issue with biopsies of renal masses?

High incidence of false-positive results.

p.3
Benign Renal Tumors

What does NSS stand for in the context of AML treatment?

Nonsurgical management or nephron-sparing surgery.

p.17
Treatment Options for RCC

When is nephron-sparing surgery (NSS) indicated?

In bilateral RCC or RCC involving a solitary functioning kidney, and in single small renal masses < 3cm with a normal opposite kidney.

p.5
Renal Cell Carcinoma (RCC)

What percentage of all adult neoplasms does RCC account for?

About 3%.

p.6
Renal Cell Carcinoma (RCC)

What type of carcinoma is observed microscopically in this pathology?

Adenocarcinoma.

p.12
Staging of Renal Tumors

What is the common lymphatic spread in RCC?

Common to hilar and retroperitoneal lymph nodes.

p.6
Renal Cell Carcinoma (RCC)

What is the prevalence of collecting duct carcinoma in renal cell carcinoma cases?

<1%.

p.9
Paraneoplastic Syndromes Associated with RCC

What is one of the symptoms of paraneoplastic syndrome associated with RCC?

Elevated ESR.

p.1
Benign Renal Tumors

What is an angiomyolipoma (AML)?

A tumor composed of fat, blood vessels, and smooth muscle.

p.11
Renal Cell Carcinoma (RCC)

When is needle aspiration or biopsy indicated for a renal mass?

When there is a suspected renal abscess or infected cyst.

Study Smarter, Not Harder
Study Smarter, Not Harder