What is a high-grade squamous intraepithelial lesion (HSIL)?
A type of VIN associated with HPV infection, typically occurring in women aged 35-50.
What staging system is used for vulval cancer?
The International Federation of Gynaecology and Obstetrics (FIGO) system.
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Vulval Intraepithelial Neoplasia (VIN)

What is a high-grade squamous intraepithelial lesion (HSIL)?

A type of VIN associated with HPV infection, typically occurring in women aged 35-50.

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Staging of Vulval Cancer

What staging system is used for vulval cancer?

The International Federation of Gynaecology and Obstetrics (FIGO) system.

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Risk Factors for Vulval Cancer

What are some risk factors for vulval cancer?

Advanced age, immunosuppression, HPV infection, and lichen sclerosus.

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Vulval Intraepithelial Neoplasia (VIN)

What is differentiated VIN associated with?

Lichen sclerosus, typically occurring in older women (aged 50-60).

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Diagnosis of VIN

What is involved in establishing the diagnosis and staging of vulval cancer?

Biopsy of the lesion, sentinel node biopsy, and further imaging (e.g., CT abdomen and pelvis).

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Types of Vulval Cancer

What is the most common type of vulval cancer?

Squamous cell carcinoma (around 90% of cases).

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Management and Referral for Vulval Cancer

What are some treatment options for VIN?

Watch and wait, wide local excision, imiquimod cream, and laser ablation.

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Management and Referral for Vulval Cancer

What is the recommended referral time for suspected vulval cancer?

A 2-week-wait urgent cancer referral.

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Symptoms of Vulval Cancer

What is the appearance of vulval cancer most frequently affecting?

The labia majora, presenting as an irregular mass, fungating lesion, ulceration, or bleeding.

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Risk Factors for Vulval Cancer

What percentage of women with lichen sclerosus develop vulval cancer?

Around 5%.

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Vulval Intraepithelial Neoplasia (VIN)

What is vulval intraepithelial neoplasia (VIN)?

A premalignant condition affecting the squamous epithelium of the vulva.

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Symptoms of Vulval Cancer

What are common symptoms of vulval cancer?

Vulval lump, ulceration, bleeding, pain, itching, and lymphadenopathy in the groin.

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Management and Referral for Vulval Cancer

What are some management options for vulval cancer?

Wide local excision, groin lymph node dissection, chemotherapy, and radiotherapy.

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