What are glycoproteins and proteoglycans?
They are types of heteropolysaccharides that perform several physiological functions.
What are glycosaminoglycans (GAGs)?
Acidic heteropolysaccharides that are constituents of proteoglycans and important structural elements of ECM and connective tissue.
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Polysaccharides: Structure and Types

What are glycoproteins and proteoglycans?

They are types of heteropolysaccharides that perform several physiological functions.

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Polysaccharides: Structure and Types

What are glycosaminoglycans (GAGs)?

Acidic heteropolysaccharides that are constituents of proteoglycans and important structural elements of ECM and connective tissue.

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Derivatives of Saccharides

What is phosphorylation in the context of saccharides?

Esterification that leads to the formation of saccharide phosphoesters, important intermediates in metabolic pathways.

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Glycosidic Bonds and Their Formation

What is the role of glycosidic bonds?

They allow the formation of oligosaccharides and polysaccharides, and the attachment of sugar moieties to proteins, nitrogen bases, and lipids.

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Monosaccharides: Structure and Types

What are the two forms in which monosaccharides can occur?

Cyclic form and open chain form.

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Classification of Saccharides

What are saccharides composed of?

Carbon, hydrogen, and oxygen.

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Monosaccharides: Structure and Types

What is the sweetest naturally occurring saccharide?

Fructose.

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Monosaccharides: Structure and Types

What is the simplest monosaccharide called?

Triose.

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Physiological Importance of Saccharides

What is galactose and its significance?

Galactose is present in lactose; failure of its metabolism can lead to liver cirrhosis, renal failure, brain damage, and cataracts.

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Physiological Importance of Saccharides

What is the function of glycogen?

Energy storage in humans.

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Physiological Importance of Saccharides

What are some physiological functions of glycoproteins and proteoglycans?

They serve as structural molecules in cellular membranes, extracellular matrix, lubricants in body fluids, hormones, and components of the immune system.

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Oligosaccharides: Structure and Types

What is lactose known as?

Milk sugar, present in milk and the main dietary saccharide of newborns.

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Polysaccharides: Structure and Types

How are polysaccharides classified?

As homopolysaccharides or heteropolysaccharides.

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Stereoisomerism of Monosaccharides

What is anomerism in monosaccharides?

Anomerism refers to the configuration of the hydroxyl group at C1; B anomerism has it on the same side as CH2OH, while A anomerism has it on opposite sides.

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Chemical Reactions of Monosaccharides

What is isomerisation in monosaccharides?

Isomerisation is the conversion of one isomer to another.

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Glycosidic Bonds and Their Formation

What types of glycosidic bonds attach polysaccharides to polypeptides?

O-glycosidic bond and N-glycosidic bond.

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Oligosaccharides: Structure and Types

How many monosaccharides are connected in oligosaccharides?

2-6 monosaccharides.

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Monosaccharides: Structure and Types

What is ribose and where is it produced?

Ribose is a pentose sugar produced in the liver in the pentose phosphate pathway and is found in RNA.

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Chemical Reactions of Monosaccharides

What enzyme is responsible for breaking down lactose?

Beta-D-galactosidase.

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Stereoisomerism of Monosaccharides

What is D/L isomerism in monosaccharides?

D isomers have the hydroxyl group on the right side of the asymmetric carbon furthest from the carbonyl, while L isomers have it on the left side.

p.2
Glycosidic Bonds and Their Formation

What are the most important esterifications of saccharides?

Phosphorylation and sulphitation.

p.5
Polysaccharides: Structure and Types

What are heteropolysaccharides composed of?

Different monosaccharide units.

p.3
Glycosidic Bonds and Their Formation

What are O-glycosidic bonds?

Bonds formed between two OH groups, found in oligosaccharides, polysaccharides, and glycoproteins.

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Oligosaccharides: Structure and Types

What is sucrose commonly known as?

Table sugar, the main dietary disaccharide.

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Physiological Importance of Saccharides

What can excessive consumption of fructose lead to?

Insulin resistance and obesity.

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Polysaccharides: Structure and Types

What are polysaccharides composed of?

More than 6 monosaccharides connected through glycosidic bonds.

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Oligosaccharides: Structure and Types

What is maltose produced from?

Alpha-amylase from starch.

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Classification of Saccharides

How are saccharides classified?

According to their number of saccharide units: monosaccharides, oligosaccharides, and polysaccharides.

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Derivatives of Saccharides

What is sorbitol and how is it formed?

Sorbitol is produced by the reduction of the aldehyde group of D-glucose and accumulates in retinal cells, leading to cataracts.

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Derivatives of Saccharides

What is mannitol and its medical significance?

Mannitol is produced by the reduction of the carbonyl group of fructose or mannose and is used to decrease brain edema and treat renal failure.

p.5
Blood Group Antigens and Their Composition

What are the blood group antigens for type B?

Gal – GlcNAc – Gal – Fuc and Gal.

p.4
Polysaccharides: Structure and Types

What percentage of starch is linear amylose?

20-25%.

p.3
Glycosidic Bonds and Their Formation

What are N-glycosidic bonds?

Bonds formed between an OH group and an NH group, found in nucleotides and glycoproteins.

p.1
Physiological Importance of Saccharides

What is the physiological importance of saccharides?

They serve as a rapid energy source, storage of energy, and structural components of nucleotides and nucleic acids.

p.3
Glycosidic Bonds and Their Formation

What type of bond is found in sucrose?

(2-1) O-glycosidic bond.

p.2
Physiological Importance of Saccharides

What is the main saccharide from a metabolic point of view?

Glucose, which is a source of energy for the CNS and erythrocytes.

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Polysaccharides: Structure and Types

What is the structure of glycogen?

Branched.

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Physiological Importance of Saccharides

Where is glycogen primarily located?

In the liver and muscles.

p.4
Physiological Importance of Saccharides

What is the most common carbohydrate in the diet?

Starch from potatoes, wheat, corn, and rice.

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Derivatives of Saccharides

What are the two main ways derivatives of saccharides are formed?

Esterification and redox reactions.

p.1
Monosaccharides: Structure and Types

What is the general formula for monosaccharides?

(CH2O)n.

p.1
Classification of Saccharides

What type of saccharide is formed from 2-6 monosaccharides linked by glycosidic bonds?

Oligosaccharides.

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Physiological Importance of Saccharides

What is the role of heparin?

It acts as an anticoagulant and is present in mast cells and endothelial cells, used to prevent blood clotting.

p.6
Derivatives of Saccharides

How is inositol produced and what is its function?

Inositol is produced by isomerization and dephosphorylation of glucose-6-phosphate and is a component of membrane phospholipids involved in signaling.

p.2
Stereoisomerism of Monosaccharides

What is epimerism?

Epimerism refers to stereoisomers that differ in configuration at one chiral carbon atom, such as glucose and mannose.

p.4
Polysaccharides: Structure and Types

What percentage of starch is branched amylopectin?

75-80%.

p.6
Derivatives of Saccharides

What role do kinases play in phosphorylation?

They catalyze the reaction that leads to the formation of saccharide phosphoesters.

p.6
Derivatives of Saccharides

What is sulphatation?

Esterification of saccharides with sulfuric acid, present in some glycosaminoglycans and cerebrosides.

p.1
Monosaccharides: Structure and Types

What are aldoses and ketoses?

Aldoses contain an aldehyde group, while ketoses contain a keto group.

p.3
Oligosaccharides: Structure and Types

What is maltose composed of?

Two molecules of glucose.

p.5
Polysaccharides: Structure and Types

Where is keratan sulfate mainly present?

In cartilages.

p.2
Physiological Importance of Saccharides

What happens to mannose in humans?

Mannose is not well metabolized in humans and is excreted uncovered into urine.

p.5
Blood Group Antigens and Their Composition

What are the blood group antigens for type A?

Gal – GlcNAc – Gal – Fuc and GalNAc.

p.6
Derivatives of Saccharides

What is glucuronic acid and how is it produced?

It is produced by the oxidation of D-glucose at carbon atom number 6 and is important for excretion of metabolic products and toxins.

p.5
Polysaccharides: Structure and Types

Where is dermatan sulfate primarily found?

In connective tissue and the lung.

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Derivatives of Saccharides

What is ribitol and its role in the body?

Ribitol is produced by the reduction of ribose and is part of flavin mononucleotide and FAD, essential for diet.

p.5
Polysaccharides: Structure and Types

What is chondroitin 6-sulfate primarily found in?

Cartilages and bones.

p.3
Oligosaccharides: Structure and Types

What are the components of sucrose?

Glucose and fructose.

p.5
Blood Group Antigens and Their Composition

What are the blood group antigens for type O?

Gal – GlcNAc – Gal – Fuc.

p.5
Physiological Importance of Saccharides

What is the function of hyaluronic acid?

It can bind water 10,000 times its own volume and functions in the vitreous body of the eye and synovial fluid.

p.2
Monosaccharides: Structure and Types

What is deoxyribose?

Deoxyribose is a derivative of ribose found in DNA.

p.3
Physiological Importance of Saccharides

What happens if the activity of beta-D-galactosidase is below a critical value?

It leads to lactose intolerance.

p.4
Polysaccharides: Structure and Types

What are the most important homopolysaccharides?

Glycogen and starch.

p.4
Glycosidic Bonds and Their Formation

What type of glycosidic bonds does amylose contain?

A(1-4) O-glycosidic bond.

p.4
Physiological Importance of Saccharides

What is the function of cellulose?

Structural component in plants and bacterial walls.

p.2
Derivatives of Saccharides

What are amino monosaccharides?

Amino monosaccharides contain an amine group replacing a hydroxyl group, with glucosamine and galactosamine being the most important.

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