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A superantigen is a bacterial product that
Binds to the beta chain of TCR and MHC class II molecules of APC stimulating T cell activation
All of the following statements about NK cells are true except
They are derived from large granular cells
1/125
p.1
Cytotoxic T Cell Activation

A superantigen is a bacterial product that

Binds to the beta chain of TCR and MHC class II molecules of APC stimulating T cell activation

p.1
General Aspects of Immune Cells

All of the following statements about NK cells are true except

They are derived from large granular cells

p.8
Autoimmune Diseases Overview

Which autoantibody is least likely associated with SLE?

Anti histone

p.10
Amyloidosis and Related Conditions

What are the characteristic structures seen in Amyloidosis?

Beta-pleated sheet, Hyaline globules

p.9
Immunodeficiency Disorders

Which cells are affected by HIV?

HIV affects CD4 cells.

p.7
Immunodeficiency Disorders

What are the characteristics of Wiskott-Aldrich syndrome?

Bloody diarrhea during infancy, low IgM and elevated IgA and IgE, large size platelets, atopic dermatitis.

p.1
Memory Cells in Immunity

Memory T cells can be identified by using the following marker

CD45RO

p.5
Cytotoxic T Cell Activation

What indicates positive tuberculin test?

Good cell mediated immunity

p.9
Autoimmune Diseases Overview

What is the most common polyarthritis condition in males?

The most common polyarthritis condition in males is gout.

p.3
MHC Class I and II Functions

The MHC Class III region genes are important elements in?

Antigen presentation and elimination

p.10
Amyloidosis and Related Conditions

Which tissue is most commonly involved in Amyloidosis?

Cardiac tissue, Renal tissue, Splenic tissue, Hepatic tissue

p.2
Cytotoxic T Cell Activation

Perforins are produced by?

Cytotoxic T cells

p.9
Amyloidosis and Related Conditions

What is the most specific stain for amyloid deposits?

Congo red is the most specific stain for amyloid deposits.

p.9
Amyloidosis and Related Conditions

What is the best method for confirming amyloidosis?

The best method for confirming amyloidosis is a rectal biopsy.

p.2
Cytotoxic T Cell Activation

The normal ratio of CD4 to CD8 is?

2:1

p.2
Immunodeficiency Disorders

Which of the following is not true about innate immunity?

It is present prior to antigenic exposure

p.1
Cytotoxic T Cell Activation

Function of CD8 is all except

Memory

p.3
General Aspects of Immune Cells

Which of the following is a type of immune cell?

Langerhans cell

p.10
Amyloidosis and Related Conditions

What is the most common site of Amyloid deposition?

Liver, Spleen, Kidney, Lung

p.2
General Aspects of Immune Cells

Antigen presenting cells are which of the following?

Endothelial cells

p.7
Immunodeficiency Disorders

Which cell type is not a target for initiation and maintenance of HIV infection?

CD4 T cell.

p.9
Amyloidosis and Related Conditions

What is the best investigation for the diagnosis of amyloidosis?

The best investigation for the diagnosis of amyloidosis is a rectal biopsy.

p.1
Hypersensitivity Reactions

Which of the following chemical mediators of inflammation is an example of a C5a or alphal chemokine?

Monocyte Chemo-attractant Protein MCP-1

p.3
MHC Class I and II Functions

True about MHC Class I?

Present in nucleated cells

p.9
Amyloidosis and Related Conditions

Which stain is specific for amyloid in tissue sections?

Periodic Acid Schiff (PAS) stain is specific for amyloid in tissue sections.

p.7
Immunodeficiency Disorders

Most common vascular tumor in AIDS patients is?

Kaposi’s sarcoma.

p.7
Autoimmune Diseases Overview

Characteristic of SLE of kidney is?

Wire loop lesions.

p.8
Immunodeficiency Disorders

What is the most common site for lymphoproliferative disorders in AIDS patients?

CNS

p.10
Amyloidosis and Related Conditions

What causes Amyloidosis related to amyloidogenic proteins?

Amyloid associated protein, Mutant calcitonin, Mutant transthyretin, Normal transthyretin

p.1
Cytotoxic T Cell Activation

The following feature is common to both cytotoxic T cells and NK cells

Effective against virus infected cells

p.2
Antibody Production Mechanisms

Which immunoglobulin is best fixed by immunoglobulins?

IgG

p.2
General Aspects of Immune Cells

Antigen presenting cells include?

Macrophage

p.3
Autoimmune Diseases Overview

MHC Class II is positively associated with?

Rheumatoid arthritis

p.2
General Aspects of Immune Cells

Marker for B-lymphocyte?

CD19

p.5
Transplant Rejection Mechanisms

True about graft-versus-host disease?

Graft must contain immunocompetent T cells

p.7
Autoimmune Diseases Overview

Becker's muscular dystrophy is also called as?

Sarcoidosis.

p.7
Autoimmune Diseases Overview

Which is not an autoimmune disease?

Syphilis.

p.7
Immunodeficiency Disorders

Chemoattraction syndrome is due to defect in?

Opsonisation.

p.1
Antibody Production Mechanisms

Which of the following is not important for which of the following?

Antibody production

p.3
General Aspects of Immune Cells

Where are immune cells found?

Spleen

p.5
Hypersensitivity Reactions

Which type of hypersensitivity reactions occur in Farmer's lung?

Type III

p.9
Immunodeficiency Disorders

What is the treatment threshold for asymptomatic HIV?

The treatment for asymptomatic HIV is done when CD4 count is below 350.

p.3
MHC Class I and II Functions

MHC Class III genes encode?

Complement component C3

p.1
Cytotoxic T Cell Activation

The following interleukin is characteristically produced in a Th2 response:

IL-4

p.5
Transplant Rejection Mechanisms

Which organ is affected in graft-versus-host disease?

Skin

p.3
MHC Class I and II Functions

MHC Class II positive cells are all except?

B cells

p.5
Transplant Rejection Mechanisms

Primary cause of death in renal transplant patients is?

Rejection

p.5
Autoimmune Diseases Overview

Which is not an autoimmune disease?

Sickle Cell Disease

p.2
Cytotoxic T Cell Activation

Which of the following immune cells have the expression of CD8 on their surface?

T-cells

p.8
Immunodeficiency Disorders

Which of the following lesions shows most specific anatomic changes in HIV infection?

Opportunistic infections

p.3
General Aspects of Immune Cells

Macrophage is derived from?

Both

p.10
Amyloidosis and Related Conditions

What type of protein is associated with Amyloidosis?

Mucopolysaccharide, Lipoprotein, Glycoprotein

p.5
Autoimmune Diseases Overview

Antibodies found in patients with myasthenia gravis are directed against?

Acetylcholine receptors

p.3
MHC Class I and II Functions

MHC is located on?

Long arm of chromosome 6

p.7
Immunodeficiency Disorders

Which immunoglobulin is absent in Ataxia telangiectasia?

IgG.

p.3
Transplant Rejection Mechanisms

Typing is useful in?

Organ transplant

p.7
Autoimmune Diseases Overview

An antibody with peripheral rim distribution is indicative of?

Anti-double stranded DNA antibody.

p.2
MHC Class I and II Functions

CD8 cells are used to identify which of the following?

MHC I

p.2
General Aspects of Immune Cells

Which one of the listed receptors is the type of receptor that binds to pathogen-associated molecular patterns?

Toll-like receptor

p.9
Autoimmune Diseases Overview

What is a mechanism for the persistence and evolution of autoimmune disease?

A mechanism for the persistence and evolution of autoimmune disease is related to the immune response.

p.1
Cytotoxic T Cell Activation

MHC restriction to antigen presentation is not done for

Killing of bacteria by helper cells

p.9
Immunodeficiency Disorders

Which virus is associated with lymphoproliferative disorders?

EBV (Epstein-Barr Virus) is associated with lymphoproliferative disorders.

p.1
Cytotoxic T Cell Activation

Natural killer cells attack which of the following cells?

Cells which express MHC1

p.8
Immunodeficiency Disorders

All of the following methods are used for the diagnosis of HIV infection in a 5-month-old child, except?

Viral culture

p.3
MHC Class I and II Functions

Mixed lymphocyte culture is used to identify?

MHC class I antigen

p.5
Transplant Rejection Mechanisms

What causes acute rejection in transplant patients?

Cytotoxic T-lymphocyte mediated injury

p.7
Immunodeficiency Disorders

Basic pathology in cystic fibrosis is?

Defect in the transport of chloride across epithelia.

p.5
Autoimmune Diseases Overview

Autoimmunity in EBV infection is the result of?

Molecular mimicry

p.2
General Aspects of Immune Cells

Cell CD marker is?

32

p.8
Autoimmune Diseases Overview

Which autoantibody is specific for SLE?

Anti RO

p.5
Cytotoxic T Cell Activation

Cell mediated immunity is?

Type IV

p.1
Cytotoxic T Cell Activation

Most potent stimulator of naive T cell is

Mature dendritic cell

p.10
Amyloidosis and Related Conditions

What are the causes of death in Amyloidosis involving kidney?

Cardiac failure, Renal failure, Sepsis, Liver failure

p.10
Amyloidosis and Related Conditions

What color is Amyloid seen as on Congo red staining?

Dark brown color, Blue color, Brilliant pink color, Khaki color

p.5
Transplant Rejection Mechanisms

Acute humoral rejection is characterized by?

Presence of anti-donor antibodies

p.7
Immunodeficiency Disorders

Most common viral antigen used for diagnosis of HIV in blood before transfusion is?

p24.

p.7
Autoimmune Diseases Overview

Lobular parotid gland enlargement is seen in all except?

Sarcoidosis.

p.8
Immunodeficiency Disorders

Regarding severe combined immunodeficiency, which of the following statements is true?

Decreased circulating lymphocytes

p.3
Antibody Production Mechanisms

Which of the following is NOT true regarding IgE antibodies?

It is involved in anti-parasitic immune responses

p.10
Amyloidosis and Related Conditions

What type of Amyloidosis is caused by mutation of the transthyretin protein?

Familial amyloidotic polyneuropathy, Dialysis associated amyloidosis, Prion protein associated amyloidosis

p.7
Autoimmune Diseases Overview

Systemic lupus erythematosus is characterized by which of the following?

LE phenomenon, rheumatoid factor, anti-nuclear factor (ANF), double stranded DNA test.

p.7
Immunodeficiency Disorders

According to WHO, the feature of class II lupus is?

Transient proteinuria.

p.5
Transplant Rejection Mechanisms

Types of grafts are called as?

Isograft, Allograft, Homograft, Xenograft

p.5
Autoimmune Diseases Overview

A young girl exposed to cold has a history of extremities followed by pain and cyanosis, what is the likely condition?

Systemic lupus erythematosus

p.2
Cytotoxic T Cell Activation

The following interleukin is characteristically produced in a TH2 response?

IL-4

p.1
MHC Class I and II Functions

Type 4 MHC presents peptide antigens to T cells so that peptide binding site is formed by

Alfa and Beta chain

p.8
Immunodeficiency Disorders

Which finding in lymphoid tissues in individuals with common variable hypogammaglobulinemia is seen?

Absent B cells

p.3
Antibody Production Mechanisms

Which of the following immunoglobulins does NOT fix complement?

IgE

p.8
Immunodeficiency Disorders

Most common CNS neoplasm in HIV patients is?

Primary CNS lymphoma

p.5
Autoimmune Diseases Overview

Antibody found in patients with myasthenia gravis is?

Acetylcholine receptors

p.9
Amyloidosis and Related Conditions

Which type of amyloidosis is caused by mutations in transthyretin?

ATTR amyloidosis is caused by mutations in transthyretin.

p.7
Autoimmune Diseases Overview

The most sensitive test for screening of 'Systemic Lupus Erythematosus' is?

Anti-nuclear antibody.

p.9
Immunodeficiency Disorders

What causes vascular graft failure?

Vascular graft failure is caused by endothelial cell dysfunction.

p.3
MHC Class I and II Functions

The role played by Major Histocompatibility Complex (MHC) is to?

Present antigens for recognition by T cell antigen receptors

p.3
MHC Class I and II Functions

Antigen presented along with MHC Class II stimulates?

CD4 cell

p.8
Immunodeficiency Disorders

Which of the following is not a feature of AIDS-related lymphoproliferative disorders?

Collection of monocytoid B – Cells in sinuses

p.7
Immunodeficiency Disorders

What indicates a diagnosis of X-linked agammaglobulinemia?

Absent tonsils and no palpable lymph nodes on physical examination, female sex, high isohemagglutinins titers, low CD3.

p.8
Immunodeficiency Disorders

Risk of HIV transmission is not seen with which of the following?

Whole blood

p.1
General Aspects of Immune Cells

Toll like receptors recognize bacterial products and stimulate immune response by

Perforin and granzyme mediated apoptosis

p.2
Memory Cells in Immunity

Cell surface molecules involved in peripheral tolerance induction are?

CD 40 and CD 40L

p.9
Amyloidosis and Related Conditions

What type of amyloidosis is associated with renal failure?

AL amyloidosis is associated with renal failure.

p.3
MHC Class I and II Functions

The epitope binding floor of the MHC molecule consists of?

Alpha and beta-1 chain

p.2
General Aspects of Immune Cells

CD16 is a marker for?

Monocyte

p.2
Immunodeficiency Disorders

Immunity against cancer cells?

NK cells

p.10
Amyloidosis and Related Conditions

What is the most common type of Amyloidosis seen?

Maturity onset DM, Type 1 DM, Type 2 DM, Equally seen with all forms of DM

p.7
Autoimmune Diseases Overview

Which of the following are found in SLE except?

Oral ulcers, psychosis, discoid rash, leucocytosis.

p.5
Transplant Rejection Mechanisms

Hypersensitivity reaction due to preformed antibodies is?

Hyperacute rejection

p.2
Hypersensitivity Reactions

Which of the following causes Dehli?

All of the above

p.2
Antibody Production Mechanisms

Plasma cells?

Helps in the formation of antibody

p.3
MHC Class I and II Functions

MHC Class I is present on?

All nucleated cells

p.7
Autoimmune Diseases Overview

Sarcoidosis does not involve?

Brain.

p.7
Autoimmune Diseases Overview

Libman-Sacks endocarditis is seen in?

SLE.

p.1
General Aspects of Immune Cells

Kwhich of the following features is not shared between T cells and B cells?

Antigen Specific Receptors

p.10
Amyloidosis and Related Conditions

What are the stains used for Amyloid?

Congo-red, Crystal violet, Methanamine silver

p.9
General Aspects of Immune Cells

What are the common clinical manifestations of sarcoidosis?

Common clinical manifestations of sarcoidosis include arthralgia, bilateral hilar adenopathy, erythema nodosum, and anterior uveitis.

p.8
Immunodeficiency Disorders

Thymic hypoplasia is seen in which of the following?

Digeorge syndrome

p.10
Amyloidosis and Related Conditions

Which diseases are associated with secondary Amyloidosis?

Alzheimer’s disease, Chronic inflammatory states, Chronic renal failure, Malignant hypertension

p.5
Autoimmune Diseases Overview

Myasthenia gravis is most commonly associated with which condition?

Thymic hyperplasia

p.9
Amyloidosis and Related Conditions

What type of amyloidosis is associated with chronic inflammatory conditions?

AA amyloidosis is associated with chronic inflammatory conditions.

p.5
Hypersensitivity Reactions

Type of hypersensitivity associated with the following: Antibody found in patients with myasthenia gravis?

Type II

p.10
Amyloidosis and Related Conditions

What are the common complications of secondary Amyloidosis?

Pneumonia, Chronic glomerulonephritis, Irritable bowel syndrome, Chronic osteomyelitis

p.2
General Aspects of Immune Cells

Antigen presenting cells present in skin are called?

Langerhan’s cells

p.3
Autoimmune Diseases Overview

MHC Class II is NOT seen in which of the following?

Ankylosing spondylitis

p.3
MHC Class I and II Functions

Major histocompatibility complex I is seen on which of the following cells?

All body cells

p.2
Cytotoxic T Cell Activation

Most potent stimulator of Naive T cells?

Mature dendritic cells

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