Bioinformatics Databases are organized collections of biological data that facilitate the storage, retrieval, and analysis of biological information, including nucleic acid and protein sequences.
Bioinformatics is a highly interdisciplinary field that combines elements from Chemistry, Biology, Mathematics, Statistics, Engineering, and Computer Science.
Bioinformatics
A variety of definitions exist in the literature and on the world wide web.
The development and application of computational tools in managing all kinds of biological data.
Metabolomics is the study of small molecules, including substrates and products of metabolic processes.
BLAST (Basic Local Alignment Search Tool) is a family of tools used for comparing an input biological sequence against a database to find regions of similarity.
Technological advances refer to the development of algorithms, computational tools, and resources that enable the analysis, manipulation, and storage of unprecedented quantities of biological sequence information.
Bioinformatics has two components: the routine storage, maintenance, and retrieval of biological data, and the analysis of biological data using various tools and techniques to create complex workflows or pipelines.
Algorithms and computational tools are used to view, analyze, and interpret genomic sequence data.
GenBank is a public database of nucleotide sequences and their protein translations, maintained by the National Center for Biotechnology Information (NCBI).
Bioinformatics provides methods for the efficient integration of various biological data sources.
The field of science in which biology, computer science, and information technology merge to form a single discipline.
Molecular profiling refers to the analysis of the molecular characteristics of cells or tissues, often used to understand disease mechanisms and guide treatment decisions.
Sequence Analysis is the process of examining the sequences of DNA, RNA, or proteins to understand their structure and function.
Restriction mapping is a technique used to determine the locations of restriction enzyme cut sites within a DNA molecule.
Protein structure prediction depends on sequence alignment data, illustrating the interaction between different aspects of bioinformatics analysis.
Bioinformatics consists of two subfields: the development of computational tools and databases, which includes writing algorithms for sequence, structural, and functional analysis, and the application of these tools and databases to generate biological knowledge for a better understanding of living systems.
GenBank is a public database of nucleotide sequences and their protein translations, maintained by the National Center for Biotechnology Information (NCBI).
Bioinformatics data resources are databases and tools that provide access to biological data, such as genomic sequences, protein structures, and metabolic pathways, which can be utilized to solve biological problems.
ClustalW is a software tool used for multiple sequence alignment, allowing researchers to align three or more sequences to identify similarities and differences.
Database construction and curation involves creating and maintaining databases that store biological data, ensuring its accuracy and accessibility for research.
The ExPASy proteomics server is a bioinformatics resource portal that provides tools and databases for protein sequence and structure analysis.
A DNA Sequence codes for an Amino Acid Sequence, which ultimately determines the structure and function of proteins.
Computational tool development is essential for performing various bioinformatics analyses, including sequence alignment, structure prediction, and functional annotation.
All metabolites present in an organism, including sugars, nucleotides, and amino acids.
Understanding your equipment is essential to effectively utilize the tools and technologies required for data analysis and to troubleshoot any issues that may arise.
Modern bioinformatics has become a discipline in its own right, characterized by being bigger, broader, and more complex than previously thought.
The integration of computer and information science into the biological field.
The number of bases in GenBank has doubled approximately every 18 months since 1982.
Transcriptomics is the study of RNA transcripts, providing a snapshot of which genes are actively being expressed by a cell or tissue at a given time.
This number represents the total number of bases sequenced in a specific whole genome shotgun project as of 15 Feb 2021.
Computational Molecular Biology refers to the computational methods used for the analysis of biological data, particularly in the context of molecular biology.
Protein Function dictates Cell Activity, influencing various biological processes within the cell.
Pairwise alignment compares two sequences, while multiple sequence alignment compares three or more sequences simultaneously to identify conserved regions.
The comprehensive analysis of metabolites in a biological sample.
Genome sequencing is the process of determining the complete DNA sequence of an organism's genome, generating sequence data and associated biological information.
Proteins whose capabilities are ultimately determined by their sequences.
GenBank statistics can be accessed via https://www.ncbi.nlm.nih.gov/genbank/statistics/
Molecular medicine is a field that focuses on the diagnosis and treatment of diseases at the molecular level, including approaches like molecular diagnosis, personalized medicine, and genetic counselling.
The goals of bioinformatics include the development of algorithms and software for analyzing biological data, the integration of biological data from various sources, and the interpretation of complex biological information.
DNA sequence assembly is the process of piecing together overlapping DNA sequences to reconstruct the original sequence from which they were derived.
Data/input sources refer to the various origins of biological data that are utilized for analysis in bioinformatics.
Reproducible results mean that the findings can be consistently obtained when the same methods and data are used, ensuring reliability.
To better understand a living cell and how it functions, at the molecular level.
Bioinformatics is a field that combines biology, computer science, and information technology to analyze and interpret biological data.
The study of the structure and function of an organism’s DNA sequence includes all protein-coding and non-coding regions within genes as well as the regions between genes.
It involves writing algorithms for sequence, structural, and functional analysis, as well as the construction and curation of biological databases.
BIOINFORMATICS is used in forensic analysis to analyze genetic information and identify individuals based on DNA profiles.
Sequence retrieval is the process of accessing and obtaining specific biological sequences from databases for further analysis or interpretation.
Applications of bioinformatics include genomics, proteomics, drug discovery, and personalized medicine, among others.
The functions of a cell can be better understood by analyzing sequence data, which provides insights into genetic and protein information.
The entire set of proteins that can be expressed by the genetic material of an organism.
The large-scale study of proteins, particularly their functions and structures.
Genome comparison involves analyzing the similarities and differences between the genomes of different organisms to understand evolutionary relationships and functional elements.
The use of computers to solve biological and biomedical questions.
Bioinformatics involves the technology that uses computers for storage, retrieval, manipulation, and distribution of information related to biological macromolecules such as DNA, RNA, and proteins.
Bioinformatics Research Services involves the analysis of biological data using a variety of tools and techniques, often in combination, to create complex workflows or pipelines.
Bioinformatics offers methods for the efficient retrieval of biological data.
GenBank® is a nucleotide sequence database that contains raw and annotated DNA sequence data.
Fundamental concepts in bioinformatics refer to the basic principles and methodologies that underpin the field, including data analysis, algorithm development, and the use of computational tools to interpret biological data.
This number represents the total number of sequences recorded in GenBank as of 15 Feb 2021.
Structure Analysis involves studying the three-dimensional arrangement of atoms in biological macromolecules to understand their function and interactions.
It implies that the information encoded in DNA ultimately determines the functions and activities of a cell.
The complete set of RNA transcripts produced by the genome at any one time.
The study of the genome, including its structure, function, evolution, and mapping.
Sequence alignment is a method used to arrange sequences of DNA, RNA, or protein to identify regions of similarity that may indicate functional, structural, or evolutionary relationships.
Metabolic pathway modelling is the representation and simulation of metabolic processes within a biological system to understand and predict metabolic behavior.
WGS refers to a method for sequencing an entire genome by randomly breaking the genome into small fragments, sequencing those fragments, and then assembling them back together.
We need bioinformatics to manage and analyze the explosive growth of biological information generated by advances in molecular biology and genomic technologies.
Major advances in molecular biology and genomic technologies, such as the automation of DNA sequencing, have led to an explosive growth in biological information.
Bioinformatics enables efficient analysis of biological data to extract meaningful insights.
Plant genome databases provide essential information for gene expression profile analyses, which are crucial for developing new crop varieties.
An Amino Acid Sequence is the order of amino acids in a protein, which is determined by the corresponding DNA Sequence.
The total amount of RNA in a cell or tissue, specifically referring to all mRNA present.
Genome sequencing is the process of determining the complete DNA sequence of an organism's genome.
The UniProt/SwissProt Knowledge Base is a comprehensive protein sequence database that provides detailed functional information about proteins.
Interpreting results is vital for drawing meaningful conclusions from the data analysis and understanding the biological implications.
Protein-protein interaction prediction is the process of forecasting the interactions between proteins based on their sequences or structures.
Information technology applied to the management and analysis of biological data.
A 'global' perspective of the cell.
The study of Proteomics involves examining all the proteins produced or modified by a cell, tissue, organ, biological fluid, or organism.
A DNA Sequence is a series of nucleotides that encode genetic information, which can be split into genes.
Function Analysis refers to the assessment of the biological roles and activities of biomolecules based on their sequences and structures.
Applications of sequence alignment include identifying homologous sequences, inferring functional and evolutionary relationships, and guiding the design of experiments.
Understanding methods and their assumptions involves knowing the techniques used for analysis and the underlying principles that may affect the results.
Protein structure classification is the categorization of proteins based on their structural features and evolutionary relationships.
Bioinformatics provides methods for the efficient storage of biological data.
The importance of bioinformatics lies in its ability to analyze complex biological data, facilitating advancements in genomics, proteomics, and personalized medicine, among other fields.
Performing analyses using bioinformatics tools involves applying computational methods and software to biological data to extract meaningful insights, identify patterns, and interpret results.
The total amount of DNA in an organism, including both coding and noncoding regions.
Genomics.
Having a plan is crucial for systematically progressing from the initial data to the final analysis, ensuring that all necessary steps are followed.
Results should be testable to allow for validation and verification of findings through further experiments or analyses.
A sequence database is a collection of biological sequences, such as DNA, RNA, or protein sequences, that can be searched and analyzed for various bioinformatics applications.
Bioinformatics is often described as the interface where computer science and biology meet and overlap.
Computerized databases are systems designed to store and organize genomic sequence information, including nucleotide and amino acid sequences.
More confined to the theoretical development of algorithms used for bioinformatics.
WGS refers to a method for sequencing an entire genome by randomly breaking it into small fragments, sequencing those fragments, and then assembling them back together.
BIOINFORMATICS aids in the identification and development of new drugs by analyzing biological data related to proteins and genes.
Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data, particularly when the data sets are large and complex.
Sequence alignment is a method used to identify similarities and differences between biological sequences, which can be DNA, RNA, or protein sequences.
The complete set of genetic material in an organism, encompassing all its DNA.
The complete set of metabolites found within a biological sample.
Bioinformatics analysis is similar to other lab analyses in that it requires careful planning, methodical execution, and critical evaluation of results.
The three aspects of bioinformatics analysis are sequence analysis, structure analysis, and functional analysis, which interact to produce integrated results.
By analysing raw molecular sequence and structural data.
The symbiotic relationship between computational and biological science.
Computational Biology encompasses all biological areas that involve computation, such as mathematical modelling of ecosystems, population dynamics, and phylogenetic construction using fossil records.
Novel proteins are newly discovered proteins whose functions are being investigated in basic genomic and molecular biology research.
ORF stands for Open Reading Frame, which is a sequence of DNA that has the potential to be translated into a protein.
The total amount of proteins expressed in a cell or tissue.
Genome assembly is the process of piecing together the short DNA sequences obtained from sequencing to reconstruct the original genome.
Bioinformatics is applied in functional proteomics to analyze protein sequences and structures, predict protein interactions, and understand protein functions.
It focuses on the application of computational tools and approaches for expanding the use of biological, medical, behavioral, or health data, including acquiring, storing, organizing, archiving, analyzing, or visualizing such data.
GenBank® contains raw and annotated DNA sequence data.
It refers to using computational tools and databases to generate biological knowledge that enhances the understanding of living systems.
Bioinformatics is limited to sequence, structural, and functional analysis of genes and genomes and their corresponding products.
A Protein folds into a specific 3D Structure, which is crucial for its function.
It started in 1990 and was completed in 2003.
The study of the transcriptome, focusing on the quantity and types of RNA produced.
Phylogenetics is the study of evolutionary relationships among biological entities, often using sequence data to reconstruct evolutionary trees.
Protein subcellular localization prediction involves determining the location of proteins within a cell, which is crucial for understanding their functions.
A research initiative that produced the human genome sequence, identifying approximately 20,500 genes and determining the sequences of the 3 billion chemical base pairs in human DNA.
Commonly used alignment tools include BLAST, Clustal Omega, and MUSCLE, which facilitate the comparison of biological sequences.
Protein Information Resources are databases that provide access to protein sequences, structures, and functional information.
Being critical and understanding potential sources of error involves recognizing factors that could lead to inaccuracies in data analysis and results interpretation.
Gene and promoter prediction involves identifying the locations of genes and their regulatory elements within a genomic sequence.
Motif discovery is the process of identifying recurring patterns or sequences in biological data that may have a biological significance.
Gene expression profiling is a technique used to measure the activity of thousands of genes at once to understand cellular responses and functions.
To identify all approximately 20,500 genes in human DNA, determine the sequences of the 3 billion chemical base pairs, store this information in databases, improve tools for data analysis, transfer related technologies to the private sector, and address ethical, legal, and social issues (ELSI).
Nucleic acid and protein structure prediction involves using computational methods to predict the three-dimensional structures of nucleic acids and proteins from their sequences.
Protein structure comparison is the analysis of the three-dimensional structures of proteins to identify similarities and differences that may indicate functional relationships.
Finding catalytic or active sites of proteins involves identifying regions within a protein structure that are responsible for its biochemical activity.
