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What happens to drugs after metabolism?
They become polar.
Which enzyme metabolizes starch?
α-amylase.
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Drug Polarization and Storage

What happens to drugs after metabolism?

They become polar.

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Enzymatic Kinetics: Michaelis-Menten Law

Which enzyme metabolizes starch?

α-amylase.

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Gastric and Intestinal Phases of Digestion

Which phases of digestion see an increase in acid secretion?

Cephalic phase and Gastric phase.

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Hydrolysis in Drug Metabolism

What process in the intestine involves hydrolysis?

Metabolism in the intestine.

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Phase 1 Metabolism

What is the conversion of L-glutamine to D-glutamine called?

Glutamate synthesis.

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Phase 1 Metabolism

What enzyme converts tyrosine to tyrosinase esterase?

Tyrosine hydroxylase.

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CYP450 Enzymes

What process requires CYP450 enzymes?

Oxidation.

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Toxic Metabolites of Drugs

What type of bond is formed by acetaminophen?

Hydrogen bond.

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Hydrolysis in Drug Metabolism

How is Amphotericin B eliminated?

By hydrolysis.

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Phase 1 Metabolism

What metabolic processes convert codeine to morphine?

Dealkylation, demethylation, oxidation.

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Phase 2 Metabolism

What is the outcome of Phase 2 metabolism?

Conjugation reactions lead to the formation of inactive substances.

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Drug Polarization and Storage

What is the most common method for drug entry into cells?

Aqueous diffusion.

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Phase 1 Metabolism

What are polysaccharides primarily composed of?

Starch.

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Drug Polarization and Storage

In what forms are drugs stored in the body?

As fat and protein.

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Toxic Metabolites of Drugs

What is the toxic metabolite of paracetamol?

N-acetyl-p-benzoquinone imine (NAPQI).

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Phase 1 Metabolism

What is the process of converting glucose from glucose called?

Glycogenesis.

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Toxic Metabolites of Drugs

What effect does aspirin have on nitrate flushing?

It reduces the flushing of nitrate.

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Metabolism of Paracetamol

What type of conjugates are formed in the metabolism of paracetamol?

Glucuronides.

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Toxic Metabolites of Drugs

What type of bond does aspirin form?

Covalent bond.

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Enzymatic Kinetics: Michaelis-Menten Law

What is the enzymatic kinetic law that describes the rate of enzymatic reactions?

Michaelis-Menten law.

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Phase 1 Metabolism

What are the main processes involved in Phase 1 metabolism and the drug?

<p>Oxidation, Reduction, Hydrolysis (diazepam)</p>

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Gastric and Intestinal Phases of Digestion

Which phase of digestion sees a decrease in acid secretion?

<p>Intestinal phase (PH=base)</p>

Study Smarter, Not Harder
Study Smarter, Not Harder