What is the smallest structure in the venous system?
Venules.
What are the characteristics of lymphatic vessels?
Larger, thicker-walled vessels with valves that ensure unidirectional flow, affected by pressure gradients.
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p.2
Microcirculation and Fluid Exchange

What is the smallest structure in the venous system?

Venules.

p.3
Flow of Lymph and Lymphatic Vessels

What are the characteristics of lymphatic vessels?

Larger, thicker-walled vessels with valves that ensure unidirectional flow, affected by pressure gradients.

p.1
Functions of the Lymphatic System

What special lymphatic capillaries are involved in the absorption and transport of fat?

Lacteals.

p.3
Components of Lymphatic System: Nodes and Organs

What is the shape and function of a lymph node?

Bean/Kidney-shaped; it filters lymph.

p.1
Microcirculation and Fluid Exchange

What materials, besides excess fluid, are leaked into the extracellular spaces?

Plasma proteins and material originating from tissue cells, such as cytoplasm from disintegrating cells.

p.1
Functions of the Lymphatic System

What is chyle?

Chyle is a milky fluid conveyed by visceral lymphatics, containing lipids and lipid-soluble vitamins absorbed by the intestine.

p.2
Microcirculation and Fluid Exchange

What are the four pressures acting on the capillaries?

Two hydrostatic pressures (capillary and tissue/interstitial) and two oncotic pressures (capillary and tissue/interstitial).

p.5
Lymphatic Tissue and Immune Surveillance

Where can lymphatic nodules be found?

In the tonsils (lingual, palatine, and pharyngeal), intestinal ileum (Peyer's patches), and appendix.

p.2
Flow of Lymph and Lymphatic Vessels

Describe the one-way flow of lymph in lymphatic capillaries.

Fluid enters via minivalves, moves towards the lumen at high pressure, and shuts the opening at low pressure.

p.4
Lymphatic Trunks and Collecting Ducts

Into how many collecting ducts do the lymphatic trunks drain?

2 collecting ducts

p.4
Flow of Lymph and Lymphatic Vessels

What forms the superior vena cava?

Left and right brachiocephalic veins

p.3
Structure and Function of Lymphatic Capillaries

What is a lacteal?

A specialized set of lymphatics large enough to absorb large molecules or chylomicrons.

p.3
Components of Lymphatic System: Nodes and Organs

How does lymph flow through a lymph node?

Lymph flows in through multiple afferent vessels and exits through one efferent vessel.

p.1
Clinical Correlations: Edema and Lymphatic Function

What is edema?

Edema is an excess of interstitial fluid, manifesting as swelling.

p.1
Functions of the Lymphatic System

What are the three main functions of the lymphatic system?

Return excess fluid to the heart, absorption and transport of fat, and immune surveillance.

p.2
Microcirculation and Fluid Exchange

What can escape from capillaries into the interstitial space?

Fluids and some proteins.

p.2
Microcirculation and Fluid Exchange

What occurs in the capillaries?

Fluid, gas, and nutrient exchange, including the continual exchange of O2 and CO2.

p.3
Flow of Lymph and Lymphatic Vessels

What happens to lymphatic vessel valves under high pressure?

They open.

p.1
Microcirculation and Fluid Exchange

What is the function of systemic capillaries in the cardiovascular system?

They are the terminal end of the cardiovascular system where a lot of fluid exchange occurs.

p.1
Flow of Lymph and Lymphatic Vessels

What is lymph?

Lymph is the fluid that flows inside the lymphatic system, including lymphatic vessels and lymph nodes.

p.5
Components of Lymphatic System: Nodes and Organs

Which lymph nodes drain the upper extremities and breast?

Axillary lymph nodes

p.5
Components of Lymphatic System: Nodes and Organs

What areas do the thoracic lymph nodes drain?

Thoracic viscera

p.5
Lymphatic Tissue and Immune Surveillance

What are diffuse lymphatic tissues?

Sparsely distributed tissues around the area with loosely arranged lymphoid cells and proteins.

p.2
Clinical Correlations: Edema and Lymphatic Function

What can result from an excess of 3 liters of fluid in the interstitial space?

Edema.

p.5
Components of Lymphatic System: Nodes and Organs

What happens to the thymus in adulthood?

It 'disappears' and is replaced by fat.

p.6
Components of Lymphatic System: Nodes and Organs

What is the function of lymphatic nodes?

Bean or kidney-shaped organs that filter lymph.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the subclavian trunk?

Upper extremities, breast

p.6
Lymphatic System's Role in Immune Defense

What are the three parts of a lymph node?

Cortex (B lymphocytes), Paracortex (T lymphocytes), Medulla (phagocytes).

p.4
Flow of Lymph and Lymphatic Vessels

What forms the right brachiocephalic vein?

Right internal jugular vein and right subclavian vein

p.3
Microcirculation and Fluid Exchange

Why can't some macromolecules be taken up by blood capillaries?

Because they are too big.

p.3
Flow of Lymph and Lymphatic Vessels

Where can lymph flow after passing through a lymphatic vessel?

Into another lymph node or directly into a lymphatic trunk.

p.1
Structure and Function of Lymphatic Capillaries

What is the role of lymphatic capillaries in preventing edema?

They prevent the accumulation of excess fluid in the extracellular spaces.

p.1
Microcirculation and Fluid Exchange

Describe the general sequence of microcirculation.

Arteries → Arteriole → Capillaries → Venules → Veins.

p.2
Microcirculation and Fluid Exchange

What happens at the arterial end of the capillary?

Net fluid has the tendency to move out of the capillary, extruding about 20 liters of fluid over 24 hours.

p.2
Structure and Function of Lymphatic Capillaries

What are the functions of anchoring/collagen filaments in lymphatic capillaries?

They allow free movement by attaching one end to the endothelial wall while the other end is unattached.

p.6
Structure and Function of Lymphatic Capillaries

What are the characteristics of lymphatic capillaries?

Blinded terminal ends inserted within the blood capillaries themselves.

p.6
Lymphatic Trunks and Collecting Ducts

What areas does the Right Lymphatic Duct collect from?

Right side of face, neck, thoracic cavity, and right upper extremities.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the thoracolumbar trunk?

Abdominal organs

p.4
Lymphatic Trunks and Collecting Ducts

Where does the left lymphatic duct drain?

Between the left internal jugular vein and left subclavian vein

p.4
Components of Lymphatic System: Nodes and Organs

What type of cells are found in the medulla of a lymph node?

Phagocytes

p.3
Flow of Lymph and Lymphatic Vessels

Describe the movement of chylomicrons after absorption in the intestine.

Intestines → lymphatic vessels → lymph nodes → ductal system.

p.5
Components of Lymphatic System: Nodes and Organs

What areas are drained by the cervical lymph nodes?

Head and Neck

p.5
Components of Lymphatic System: Nodes and Organs

Which lymph nodes drain the lower limbs?

Inguinal lymph nodes

p.5
Lymphatic Tissue and Immune Surveillance

What are lymphatic nodules?

Discrete concentrations of lymphocytes without an outer covering or capsule.

p.6
Overview of the Circulatory System

What is the origin of the lymphatic system?

Excess fluid not reabsorbed by the blood capillaries (~3L).

p.6
Flow of Lymph and Lymphatic Vessels

What are the features of lymphatic vessels?

Larger, thicker walled vessels with valves.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the jugular trunk?

Head and Neck

p.4
Lymphatic Trunks and Collecting Ducts

What is the cisterna chyli?

An enlarged, starting portion of the intestinal trunk that pierces the diaphragm and enters the thoracic cavity

p.4
Lymphatic System's Role in Immune Defense

What do lymph nodes contain to fend off foreign substances?

Antibodies

p.3
Structure and Function of Lymphatic Capillaries

What is the function of the blinded terminal ends of lymphatic capillaries?

They are inserted within the blood capillaries themselves to take up any excess fluid thrown into the extracellular space.

p.1
Overview of the Circulatory System

What are the two main components of the circulatory system?

The Cardiovascular System and The Lymphatic System.

p.2
Microcirculation and Fluid Exchange

What type of blood do arterioles carry to the capillaries?

Oxygen-rich blood.

p.5
Components of Lymphatic System: Nodes and Organs

What areas are drained by the popliteal lymph nodes?

Legs

p.2
Microcirculation and Fluid Exchange

What happens at the venous end of the capillary?

Fluid tends to move back into the capillary, reabsorbing 17 of the 20 liters extruded from the arteriolar end.

p.2
Structure and Function of Lymphatic Capillaries

What are minivalves in lymphatic capillaries?

Unattached portions or ends of endothelial cells that allow fluid movement towards the lumen of the lymphatic capillary.

p.6
Lymphatic Trunks and Collecting Ducts

What are lymphatic trunks and what do they include?

Larger and thicker vessels that include lumbar trunks (2), intestinal trunk, bronchomediastinal trunk, subclavian trunk, and jugular trunk.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the intestinal trunk?

Intestines (via lymphatic lacteals)

p.6
Components of Lymphatic System: Nodes and Organs

What are lymphatic organs and what do they include?

Encapsulated and larger than lymphatic nodules, includes lymph nodes, thymus, and spleen.

p.4
Components of Lymphatic System: Nodes and Organs

What is the function of phagocytes in the lymph node medulla?

To engulf foreign material

p.3
Flow of Lymph and Lymphatic Vessels

What happens to lymphatic vessel valves under low pressure?

They close.

p.1
Microcirculation and Fluid Exchange

How much excess fluid is thrown into the extracellular spaces daily?

At least 3 liters.

p.2
Microcirculation and Fluid Exchange

What is the structure of capillaries?

Capillaries contain a single layer of endothelial cells and are very porous due to the presence of fenestrations.

p.5
Components of Lymphatic System: Nodes and Organs

Which lymph nodes are responsible for draining the pelvic region?

Abdominal lymph nodes

p.5
Components of Lymphatic System: Nodes and Organs

What distinguishes lymphatic organs from lymphatic nodules?

Lymphatic organs are larger and have a capsule.

p.5
Components of Lymphatic System: Nodes and Organs

Where is the spleen located?

Inside the abdominal cavity, related to the GI tract (left, lateral to the stomach and splenic flexure of the colon, anterior to the kidney).

p.2
Components of Lymphatic System: Nodes and Organs

What is the specialized set of lymphatics in the intestinal epithelium called?

Lacteals.

p.6
Flow of Lymph and Lymphatic Vessels

Describe the connection of the subclavian vein on the left side.

Left internal jugular vein + Left subclavian vein → Left Brachiocephalic vein.

p.4
Lymphatic Trunks and Collecting Ducts

Which trunks drain into the right lymphatic duct?

Right subclavian trunk, right jugular trunk, right bronchomediastinal trunk

p.1
Components of Lymphatic System: Nodes and Organs

What are the important parts of the lymphatic system?

Lymphatic capillaries, lymphatic vessels, lymphatic trunks, lymph nodes, lymphocytes, lymphatic organs, and collecting ducts.

p.5
Components of Lymphatic System: Nodes and Organs

What areas do the tracheobronchial lymph nodes drain?

Lungs and mediastinum

p.2
Microcirculation and Fluid Exchange

What is hydrostatic pressure?

The force of a fluid in a contained environment, also known as 'push' pressure.

p.2
Structure and Function of Lymphatic Capillaries

What makes lymphatic capillaries very permeable to fluid?

The loosely packed cell arrangement of their single layer of endothelial cells.

p.2
Flow of Lymph and Lymphatic Vessels

What is interstitial fluid called once it enters the lymphatic vessel?

Lymph.

p.6
Components of Lymphatic System: Nodes and Organs

How does lymph enter and exit lymphatic nodes?

Lymph enters via multiple afferent vessels and exits via a single efferent vessel.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the bronchomediastinal trunk?

Lungs, mediastinum

p.6
Lymphatic Tissue and Immune Surveillance

What are lymphatic nodules and what do they include?

Discrete and packed concentration of lymphocytes, not encapsulated, includes tonsils, Peyer’s patches, and appendix.

p.4
Components of Lymphatic System: Nodes and Organs

What type of cells are found in the cortex of a lymph node?

B-lymphocytes

p.3
Lymphatic Trunks and Collecting Ducts

What are lymphatic trunks?

Larger and thicker lymphatic vessels that include three pairs of trunks in the thoracic cavity.

p.2
Microcirculation and Fluid Exchange

What is the smallest structure in the arterial system?

Arterioles.

p.5
Components of Lymphatic System: Nodes and Organs

Which lymph nodes are responsible for draining the lower group of nodes including iliac and inguinal?

Aortic lymph nodes

p.2
Microcirculation and Fluid Exchange

What is oncotic pressure?

Pressure brought about by proteins inside the plasma or blood vessels, also known as 'pull' pressure.

p.5
Components of Lymphatic System: Nodes and Organs

Where is the thymus located and what is its function?

Located in the thoracic cavity (anterior mediastinum), it produces T-cells.

p.6
Lymphatic Trunks and Collecting Ducts

What are the two collecting ducts in the lymphatic system?

Right Lymphatic Duct and Thoracic Duct.

p.6
Flow of Lymph and Lymphatic Vessels

What is the final connection of the left and right Brachiocephalic veins?

Left + Right Brachiocephalic vein → Superior Vena Cava (SVC).

p.4
Lymphatic Trunks and Collecting Ducts

Where does the right lymphatic duct drain?

Between the right internal jugular vein and right subclavian vein

p.2
Microcirculation and Fluid Exchange

What do venules do?

Venules receive fluid from the capillaries and deliver blood to the veins.

p.2
Structure and Function of Lymphatic Capillaries

Where are lymphatic capillaries located?

Inserted in between the blood capillaries.

p.6
Overview of the Circulatory System

Describe the organization of the lymphatic system.

The lymphatic system includes lymphatic capillaries, vessels, nodes, trunks, and collecting ducts.

p.6
Lymphatic Tissue and Immune Surveillance

What is diffuse lymphatic tissue and where is it distributed?

Accumulation of lymphatic tissue in MALT, distributed sparsely in the intestines and respiratory tracts.

p.5
Components of Lymphatic System: Nodes and Organs

What areas are drained by the intestinal and mesenteric lymph nodes?

Abdominal viscera

p.5
Components of Lymphatic System: Nodes and Organs

What are the main lymphatic organs?

Lymph nodes, thymus, and spleen.

p.6
Flow of Lymph and Lymphatic Vessels

Describe the connection of the subclavian vein on the right side.

Right internal jugular vein + Right subclavian vein → Right Brachiocephalic vein.

p.4
Lymphatic Trunks and Collecting Ducts

Which trunks drain into the left lymphatic duct?

Left subclavian trunk, left jugular trunk, left bronchomediastinal trunk, cisterna chyli (intestinal trunk, lumbar trunk)

p.4
Components of Lymphatic System: Nodes and Organs

What type of cells are found in the paracortex of a lymph node?

T-lymphocytes

p.5
Lymphatic Tissue and Immune Surveillance

What is MALT and where is it found?

Mucosa-associated lymphatic tissue, found in the mucosa of the trachea, intestine, GI tract, and respiratory tract.

p.5
Overview of the Circulatory System

Describe the production of lymph.

Lymph is fluid flowing through the lymphatic system, originating as interstitial (tissue) fluid that enters the lymphatic vessels.

p.6
Lymphatic Trunks and Collecting Ducts

What areas does the Thoracic Duct collect from?

All other areas not drained into the right lymphatic duct.

p.4
Lymphatic Trunks and Collecting Ducts

What areas are drained by the lumbar trunk?

Lower limbs & pelvic organs

p.4
Flow of Lymph and Lymphatic Vessels

What forms the left brachiocephalic vein?

Left internal jugular vein and left subclavian vein

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