Where is the spleen located?
In the upper left abdomen close to the diaphragm.
What cells are predominantly found in the superficial layer of the lymph node cortex?
B-cells and macrophages.
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p.3
Spleen Anatomy and Functions

Where is the spleen located?

In the upper left abdomen close to the diaphragm.

p.4
Lymph Nodes and Immune Response

What cells are predominantly found in the superficial layer of the lymph node cortex?

B-cells and macrophages.

p.5
Lymph Nodes and Immune Response

How does lymph enter the lymph nodes?

Lymph follows afferent lymphatic vessels to get into the subcapsular sinus of lymph nodes.

p.3
Thymus Function and Structure

What are the two main regions of the thymus?

The outer cortex and the inner medulla.

p.1
Lymphatic Capillaries

What forms the structure of lymphatic capillaries?

A single layer of endothelial cells whose edges overlap each other to form minivalves.

p.5
Lymphatic Nodules and Peyer's Patches

What are Peyer's patches?

Aggregates of lymphoid nodules in the ileum of the small intestine.

p.3
Spleen Anatomy and Functions

What is the largest lymphatic organ in the body?

The spleen.

p.1
Lymphatic Capillaries

Why does lymph not flow back into the tissue from lymphatic capillaries?

The higher pressure in tissue fluid causes the minivalve flaps to press together, preventing backflow.

p.4
Lymph Nodes and Immune Response

What are the main structural components of a lymph node when cut at a sagittal plane?

An outer cortex and an inner medulla.

p.2
Lymphatic Ducts

What is the function of the thoracic duct?

It is responsible for draining lymph from the right lower part and the whole left side of the body.

p.5
Lymph Nodes and Immune Response

What happens to lymph after it enters the subcapsular sinus of lymph nodes?

It flows into trabecular sinuses close to the trabeculae and then into medullary sinuses or diffuses through lymphatic nodules before reaching the medullary sinuses.

p.3
Thymus Function and Structure

What happens to the thymus after puberty?

It begins to degenerate slowly, and fat accumulates in the organ, causing it to turn yellow at old age.

p.1
Lymphatic Capillaries

Where are lymphatic capillaries found?

In spaces between tissue cells, intertwining with blood capillaries in a capillary bed.

p.4
Lymph Nodes and Immune Response

What is the primary function of lymph nodes?

To filter out foreign substances and kill pathogens such as bacteria and viruses in the lymph.

p.2
Primary and Secondary Lymphatic Organs

What are the secondary lymphatic organs?

The spleen, lymph nodes, tonsils, and lymphatic nodules.

p.1
Unidirectional Lymph Flow

How is lymph propelled along lymphatic vessels?

By the squeezing effect caused by contractions of nearby skeletal muscles and pulsations of neighboring arteries.

p.4
Lymph Nodes and Immune Response

What cells are predominantly found in the deep cortex (paracortex) of the lymph node?

T-cells.

p.2
Lymphatic Ducts

How long is the right lymphatic duct?

About 1 cm long.

p.2
Lymphatic Ducts

Where does the thoracic duct arise from?

It arises as an enlarged sac called the cisterna chyli, situated at the first and second lumbar level.

p.5
Lymphatic Nodules and Peyer's Patches

What is the function of lymphocytes in lymphatic nodules?

They kill pathogens that travel along the digestive tract and generate a diverse range of memory lymphocytes from sampling different antigens.

p.3
Thymus Function and Structure

What is the primary function of the thymus?

It provides a site for the maturation of T-cells.

p.1
Lymphatic Capillaries

What are lymphatic capillaries and what is their function?

Lymphatic capillaries are small, closed-end vessels that collect and carry away excess tissue fluid.

p.1
Lymphatic Ducts

Where do the lymphatic ducts empty the lymph?

The lymphatic ducts empty the lymph back into the bloodstream at the root of the neck.

p.5
Tonsils and Their Role in Immunity

What might be required if tonsils are repeatedly infected?

Surgical removal (tonsillectomy).

p.3
Thymus Function and Structure

Where is the thymus located?

Between the sternum and the upper part of the heart.

p.3
Spleen Anatomy and Functions

What is the function of the red pulp in the spleen?

It is where aged, damaged, and abnormal red blood cells are broken down and recycled.

p.4
Lymph Nodes and Immune Response

What are the two types of lymph nodes?

Superficial and deep lymph nodes.

p.2
Lymphatic Ducts

What is the function of the right lymphatic duct?

It is responsible for draining lymph from the right upper part of the body.

p.2
Lymphatic Ducts

Where do the lymphatic ducts empty their lymph?

Into venous circulation at the junction of the internal jugular and subclavian veins on each side of the body.

p.2
Lacteals and Lipid Absorption

What happens to the lymph inside lacteals when it is rich in lipid?

It turns milky, hence lacteals are also known as white and milky veins.

p.3
Thymus Function and Structure

Where do immature T-cells first colonize in the thymus?

The cortex.

p.1
Lymphatic Capillaries

How does tissue fluid enter lymphatic capillaries?

When there is an increase in pressure in tissue fluid, the minivalves are pushed open, allowing tissue fluid to enter the lymphatic capillaries and become lymph.

p.4
Lymph Nodes and Immune Response

How does lymph enter and exit a lymph node?

Lymph enters through several afferent lymphatic vessels and exits through one to two efferent lymphatic vessels at the hilum.

p.4
Lymph Nodes and Immune Response

What is the function of the sinuses in the lymph node?

To support the flow of lymph and enhance the filtering effect.

p.5
Lymph Nodes and Immune Response

How does lymph leave the lymph nodes?

Lymph flows into efferent lymphatic vessels to leave the lymph node.

p.5
Lymphatic Nodules and Peyer's Patches

Where can lymphatic nodules be found in high concentration?

In the ileum of the small intestine and the appendix of the large intestine.

p.4
Lymph Nodes and Immune Response

Where are lymph nodes distributed in the body?

Lymph nodes are widely distributed in the body and usually occur in clusters or chains.

p.2
Lymphatic Ducts

What are the two main lymphatic ducts in the body?

The right lymphatic duct and the thoracic duct.

p.2
Lacteals and Lipid Absorption

What are lacteals and where are they located?

Lacteals are specialized lymphatic vessels present in the intestines.

p.2
Lacteals and Lipid Absorption

What is the function of lacteals?

They are important for the absorption and transportation of lipids or chylomicrons in the body.

p.2
Primary and Secondary Lymphatic Organs

What are the primary lymphatic organs and their functions?

Red bone marrow and thymus are primary lymphatic organs where maturation of lymphocytes takes place.

p.5
Tonsils and Their Role in Immunity

Where are tonsils located?

Tonsils are located in the pharyngeal region at the top of the throat.

p.3
Spleen Anatomy and Functions

What is the function of the white pulp in the spleen?

It allows a rapid immune response against blood-borne antigens.

p.1
Lymphatic Ducts

Into what larger structures is lymph drained before entering the bloodstream?

Lymph is drained into larger lymph trunks, which then unite to form two lymphatic ducts.

p.2
Lymphatic Ducts

How long is the thoracic duct?

40 cm.

p.2
Primary and Secondary Lymphatic Organs

Where do B-lymphocytes and T-lymphocytes mature?

B-lymphocytes mature in the bone marrow, while T-lymphocytes mature in the thymus.

p.5
Tonsils and Their Role in Immunity

What is the function of the ring of lymphoid tissue formed by the tonsils?

To collect and remove pathogens entering the body from inhaled air via the nasal cavity and swallowed food via the oral cavity.

p.1
Unidirectional Lymph Flow

What structural features do lymphatic vessels have to prevent backflow of lymph?

Lymphatic vessels have thin walls and abundant valves, each containing two semilunar flaps.

p.2
Primary and Secondary Lymphatic Organs

What common feature do the spleen, lymph nodes, and thymus share?

They all have a dense, fibrous capsule around them, providing physical support and forming paths for blood vessels, efferent lymphatic vessels, and nerves.

p.3
Thymus Function and Structure

When is the thymus most active?

When a person is young.

p.3
Spleen Anatomy and Functions

How does the spleen act as a blood reservoir?

It can release as much as 100 mL of blood into circulation to supplement blood loss.

p.4
Lymph Nodes and Immune Response

What is the normal size range of lymph nodes?

About 1 mm to 2 cm in length.

p.5
Tonsils and Their Role in Immunity

Which tonsils are the largest and most often infected in childhood?

The palatine tonsils.

p.3
Spleen Anatomy and Functions

What are the two main types of tissues in the spleen?

The white pulp and the red pulp.

p.1
Unidirectional Lymph Flow

How is lymph transported in the body?

Lymph is transported to larger lymphatic collecting vessels as capillaries merge together.

p.4
Lymph Nodes and Immune Response

What is the reticular meshwork in a lymph node composed of?

Reticular cells and fibers.

p.5
Lymph Nodes and Immune Response

What role do lymphocytes and macrophages play in the lymph nodes?

They monitor the contents of the lymph and clear harmful micro-organisms like pathogens or tumour cells.

p.5
Tonsils and Their Role in Immunity

What are the four groups of tonsils?

Pharyngeal tonsil (adenoid), tubal tonsils, palatine tonsils, and lingual tonsils.

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