Name an example of an over-the-counter PPI.
Omeprazole (Prilosec).
What is the role of antacids?
To neutralize stomach acid.
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Proton Pump Inhibitors (PPIs)

Name an example of an over-the-counter PPI.

Omeprazole (Prilosec).

p.1
Antacids

What is the role of antacids?

To neutralize stomach acid.

p.9
Proton Pump Inhibitors (PPIs)

What is a third example of a PPI?

Lansoprazole (Prevacid).

p.8
Proton Pump Inhibitors (PPIs)

By what percentage can PPIs reduce gastric acid secretion?

80 to 95%.

p.8
Proton Pump Inhibitors (PPIs)

What anti-inflammatory properties do PPIs have?

They may help decrease gastric irritation.

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Adverse Effects of H2 Receptor Blockers

What is a potential issue with long-term use of H2 receptor blockers?

Tolerance.

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Antacids

What is the primary function of antacids?

To neutralize HCl in the stomach.

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Adverse Effects of H2 Receptor Blockers

What are some mild gastrointestinal problems associated with H2 receptor blockers?

Nausea, diarrhea, and constipation.

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Adverse Effects of Proton Pump Inhibitors

What is a potential adverse effect of PPIs related to stomach acid?

Acid rebound.

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H2 Receptor Blockers

What are H2 receptor blockers used for?

They are used to reduce stomach acid production.

p.8
Proton Pump Inhibitors (PPIs)

What enzyme do Proton Pump Inhibitors (PPIs) inhibit?

H+, K+-ATPase enzyme.

p.10
Adverse Effects of Proton Pump Inhibitors

How are Proton Pump Inhibitors (PPIs) generally tolerated?

They are generally well-tolerated.

p.3
OTC vs Prescription Medications

What distinguishes OTC antacids from prescription antacids?

OTC antacids can be purchased without a prescription, while prescription antacids require a doctor's approval.

p.1
Gastrointestinal Drug Categories

What are the main categories of gastrointestinal drugs?

Antacids, H2 receptor blockers, and proton pump inhibitors.

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Proton Pump Inhibitors (PPIs)

What is another example of a PPI?

Esomeprazole (Nexium).

p.1
Emesis/ Vomiting

What is emesis?

The medical term for vomiting.

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Adverse Effects of Antacids

What phenomenon can occur after stopping antacid use?

Acid rebound.

p.3
Antacids

What are the types of antacids?

Aluminum-containing, magnesium-containing, calcium carbonate-containing, sodium bicarbonate-containing, and combination.

p.3
Antacids

In what forms can antacids be taken?

Tablets and liquid oral suspension.

p.9
Proton Pump Inhibitors (PPIs)

What is a key characteristic of PPIs?

They have a safe profile.

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Adverse Effects of Proton Pump Inhibitors

What are some risks associated with the use of PPIs?

Increased risk of certain infections, decreased absorption of certain nutrients (vitamin B, magnesium, iron), and kidney problems such as interstitial nephritis.

p.1
H2 Receptor Blockers

What do H2 receptor blockers do?

They reduce gastric acid production by blocking histamine receptors in the stomach.

p.5
H2 Receptor Blockers

What do H2 receptor blockers prevent?

The histamine-activated release of gastric acid.

p.9
Proton Pump Inhibitors (PPIs)

How are PPIs typically administered?

Orally, in tablets or capsules.

p.5
H2 Receptor Blockers

What is the role of histamine in gastric acid secretion?

Histamine activates the release of gastric acid.

p.2
Antacids

What types of bases do antacids typically contain?

Carbonate or hydroxide.

p.2
Antacids

What additional protection can antacids containing aluminium provide?

They may inhibit Helicobacter pylori infection and enhance the production of prostaglandins, proteins, and growth factors.

p.9
Proton Pump Inhibitors (PPIs)

What are Proton Pump Inhibitors (PPIs) used for?

To reduce gastric acid production.

p.10
Adverse Effects of Proton Pump Inhibitors

How do PPIs affect calcium metabolism?

They can affect calcium metabolism.

p.3
Antacids

What are antacids?

Over-the-counter products used to neutralize stomach acid.

p.2
Antacids

How do antacids increase intragastric pH?

By combining with excess hydrogen ions (H+) in the stomach.

p.3
Antacids

What is a common route of administration for antacids?

Orally.

p.7
Adverse Effects of H2 Receptor Blockers

What musculoskeletal symptoms have been reported with cimetidine use?

Arthralgia and myalgia.

p.7
Adverse Effects of H2 Receptor Blockers

What phenomenon can occur after stopping H2 receptor blockers?

Acid rebound.

p.7
Adverse Effects of H2 Receptor Blockers

How are H2 receptor blockers generally tolerated?

They are generally well-tolerated.

p.8
Proton Pump Inhibitors (PPIs)

What bacterial infection may PPIs have anti-bacterial effects against?

H. pylori infection.

p.8
Proton Pump Inhibitors (PPIs)

What is the drug of choice for long-term treatment of gastric and duodenal ulcers and GERD?

Proton Pump Inhibitors (PPIs).

p.6
H2 Receptor Blockers

What is the safety profile of H2 receptor blockers?

They have a safe profile.

p.5
H2 Receptor Blockers

What do H2 receptor blockers bind to in the gastric mucosa?

H2 receptors.

p.4
Adverse Effects of Antacids

What is a common adverse effect of aluminum-based antacids?

Constipation.

p.1
Emesis/ Vomiting

What can cause excessive emesis?

Conditions like pregnancy, infections, or gastrointestinal disorders.

p.4
Adverse Effects of Antacids

Why should antacids not be used for extended periods?

Due to potential adverse effects.

p.10
Adverse Effects of Proton Pump Inhibitors

What type of gastric condition can PPIs cause that may predispose patients to GI tumors?

Gastric polyps.

p.5
H2 Receptor Blockers

How do H2 receptor blockers help with NSAID use?

They decrease damage from gastric acid caused by NSAIDs.

p.9
OTC vs Prescription Medications

What are two categories of availability for PPIs?

Prescription and over-the-counter (OTC) products.

p.6
H2 Receptor Blockers

What are some examples of H2 receptor blockers?

Cimetidine (Tagamet), Famotidine (Pepcid), Ranitidine (Zantac).

p.6
OTC vs Prescription Medications

Can H2 receptor blockers be obtained over-the-counter?

Yes, they are available as both prescription and over-the-counter products.

p.4
Adverse Effects of Antacids

What are potential risks of using antacids for extended periods?

Electrolyte imbalances and altered pharmacokinetics.

p.6
H2 Receptor Blockers

What forms do H2 receptor blockers come in?

They are available in tablets, capsules, and liquid oral suspension.

p.6
H2 Receptor Blockers

What routes are available for administering H2 receptor blockers?

They can be taken orally in the form of tablets, capsules, or liquid oral suspension.

p.1
Gastrointestinal Motility

What can lead to inadequate gastrointestinal motility?

Conditions such as diabetes, certain medications, or neurological disorders.

p.1
Proton Pump Inhibitors (PPIs)

What is the function of proton pump inhibitors (PPIs)?

To inhibit the proton pump in the stomach lining, reducing gastric acid secretion.

p.5
H2 Receptor Blockers

What conditions are H2 blockers used to manage?

Peptic ulcer, dyspepsia, and gastro-esophageal reflux disease (GERD).

p.1
Gastrointestinal Motility

What is gastrointestinal motility?

The movement of food through the digestive tract.

p.4
Adverse Effects of Antacids

What adverse effect is associated with magnesium-based antacids?

Diarrhea.

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