Increased blood solute concentration affects ___ neurons.
hypothalamic
The thick segment of the ascending limb is impermeable to both ___ and ___.
water, solutes
1/166
p.13
Hormonal Regulation of Urine Concentration

Increased blood solute concentration affects ___ neurons.

hypothalamic

p.3
Loop of Henle Structure and Function

The thick segment of the ascending limb is impermeable to both ___ and ___.

water, solutes

p.19
Micturition Reflex and Urinary Bladder Anatomy

Females have smooth muscle fibers at the neck of the bladder that assist with preventing ___ leakage.

urine

p.12
Hormonal Regulation of Urine Concentration

Even slight changes in solute concentration will trigger ___ release.

ADH

p.16
Hormonal Regulation of Urine Concentration

Dilation of renal arteries increases ___ production.

urine

p.15
Hormonal Regulation of Urine Concentration

The regulation of blood volume has a direct effect on ___ volume.

urine

p.2
Reabsorption Mechanisms in the Kidney

The loop of Henle is a critical location for ___ reabsorption.

water

p.23
Body Fluid Compartments and Regulation

The extracellular fluid compartment accounts for around ___% of all the water in the body.

30

p.19
Micturition Reflex and Urinary Bladder Anatomy

Both males and females have a well-defined external urethral ___ formed of skeletal muscle.

sphincter

p.12
Hormonal Regulation of Urine Concentration

ADH promotes water conservation in the kidneys by increasing the permeability of the distal convoluted tubules and collecting ducts to ___.

water

p.12
Hormonal Regulation of Urine Concentration

This allows more water to be reabsorbed from the filtrate and the kidneys to produce a small volume of ___ urine.

concentrated

p.9
Reabsorption Mechanisms in the Kidney

The volume of the filtrate does not change as it passes through the ___ limbs.

ascending

p.15
Hormonal Regulation of Urine Concentration

Homeostasis involves the regulation of ___ volume in the body.

blood

p.13
Hormonal Regulation of Urine Concentration

ADH increases the permeability of the collecting duct to water by stimulating the insertion of ___ proteins.

aquaporin

p.3
Reabsorption Mechanisms in the Kidney

The cells of the thick segment house multiple types of transport proteins including ___-powered pumps.

ATP

p.23
Body Fluid Compartments and Regulation

Intracellular fluid has a relatively high concentration of ions such as K+, magnesium (Mg2+), and ___ compared to extracellular fluid.

phosphate (PO4^3−)

p.19
Micturition Reflex and Urinary Bladder Anatomy

The external urethral sphincter allows a person to voluntarily start or stop the flow of ___ through the urethra.

urine

p.19
Micturition Reflex and Urinary Bladder Anatomy

The female urethra is approximately ___ cm long.

4

p.6
Countercurrent Mechanisms in Kidney Function

The permeability changes in the loop of Henle are crucial for its role in the ___ mechanism.

countercurrent

p.6
Countercurrent Mechanisms in Kidney Function

The vasa recta maintains the high solute concentration in the ___ fluid.

interstitial

p.6
Medullary Concentration Gradient

The medullary concentration gradient develops from the actions of countercurrent mechanisms and the recycling of ___.

urea

p.7
Countercurrent Mechanisms in Kidney Function

The concentration gradient from the cortex to the inner medulla increases from ___ mOsm/L to ___ mOsm/L.

300, 1200

p.7
Countercurrent Mechanisms in Kidney Function

The advantage of producing 180 L of filtrate daily and reabsorbing ___ L (99%) is to maintain the medullary concentration gradient.

178

p.5
Hormonal Regulation of Urine Concentration

The distal convoluted tubule and collecting duct can change their permeability to water due to ___ regulation.

hormone

p.22
Micturition Reflex and Urinary Bladder Anatomy

Parasympathetic action potentials cause the urinary bladder to ___.

contract

p.11
Renin-Angiotensin-Aldosterone System

Low blood pressure stimulates renin secretion from the ___.

kidney

p.11
Renin-Angiotensin-Aldosterone System

Renin stimulates the production of angiotensin I, which is converted to ___.

angiotensin II

p.18
Micturition Reflex and Urinary Bladder Anatomy

Immunotherapy for superficial tumors may involve the use of a medicine known as ___ Calmette-Guérin (BCG).

Bacillus

p.11
Renin-Angiotensin-Aldosterone System

Drugs that increase urine volume are called ___.

diuretics

p.10
Renin-Angiotensin-Aldosterone System

Angiotensin I is converted to angiotensin II by the angiotensin-converting enzyme (ACE) produced by ___ of organs such as the lungs.

capillaries

p.21
Micturition Reflex and Urinary Bladder Anatomy

The majority of kidney stones consist mainly of ___ oxalate.

calcium

p.13
Hormonal Regulation of Urine Concentration

ADH increases water reabsorption by the ___.

kidney

p.13
Hormonal Regulation of Urine Concentration

ADH secretion is regulated by changes in ___ pressure.

blood

p.17
Micturition Reflex and Urinary Bladder Anatomy

The most common cause of cystitis is infection by the bacterium ___ ___ .

E. coli

p.23
Body Fluid Compartments and Regulation

Plasma is the liquid portion of the blood found inside all the blood vessels in the ___.

body

p.3
Reabsorption Mechanisms in the Kidney

Cl− and K+ exit the cells of the ascending limb via ___ diffusion.

facilitated

p.19
Micturition Reflex and Urinary Bladder Anatomy

The male urethra is approximately ___ cm long.

20

p.19
Micturition Reflex and Urinary Bladder Anatomy

The female urethra opens into the vestibule anterior to the ___ opening.

vaginal

p.14
Hormonal Regulation of Urine Concentration

When baroreceptors detect a large increase in blood pressure, ADH secretion ___ .

decreases

p.10
Hormonal Regulation of Urine Concentration

When body fluid concentration rises, increased water reabsorption results in a small volume of ___ urine.

concentrated

p.10
Hormonal Regulation of Urine Concentration

A decrease in body fluid concentration leads to decreased water reabsorption and a large volume of ___ urine.

dilute

p.16
Hormonal Regulation of Urine Concentration

A large volume of IV saline solution will cause blood volume to ___ and thus blood pressure to ___ .

increase, increase

p.7
Countercurrent Mechanisms in Kidney Function

The cells of the thick segment of the ascending limb actively ___ solutes into the interstitial fluid.

pump

p.5
Reabsorption Mechanisms in the Kidney

Tubular secretion is the movement of nonfiltered substances from the blood into the ___.

filtrate

p.21
Micturition Reflex and Urinary Bladder Anatomy

The contraction of abdominal muscles increases ___ pressure, enhancing the micturition reflex.

abdominal

p.5
Reabsorption Mechanisms in the Kidney

H +, K +, and penicillin are actively secreted by either active transport or ___ transport processes.

counter

p.11
Renin-Angiotensin-Aldosterone System

The reabsorption of water following Na+ and Cl- increases blood volume, which in turn increases blood ___.

pressure

p.18
Micturition Reflex and Urinary Bladder Anatomy

The walls of the ureter and urinary bladder are composed of layers of smooth muscle and ___ tissue.

connective

p.5
Hormonal Regulation of Urine Concentration

The kidneys' ability to control urine volume and concentration depends on three factors: countercurrent mechanisms, a medullary concentration gradient, and ___ mechanisms.

hormonal

p.21
Micturition Reflex and Urinary Bladder Anatomy

The ability to voluntarily inhibit micturition typically develops at the age of ___ years.

2–3

p.21
Micturition Reflex and Urinary Bladder Anatomy

Increasing fluid intake to produce at least ___ liters of urine each day helps prevent kidney stones.

2

p.15
Hormonal Regulation of Urine Concentration

Changes in blood volume can influence urine ___ and concentration.

volume

p.23
Body Fluid Compartments and Regulation

The intracellular fluid compartment accounts for about ___% of the body's total weight.

40

p.4
Reabsorption Mechanisms in the Kidney

By the time the fluid reaches the distal convoluted tubule, the concentration of the filtrate is reduced to about ___ mOsm/L.

100

p.6
Countercurrent Mechanisms in Kidney Function

The kidneys utilize a ___ mechanism for fluid exchange.

countercurrent

p.6
Countercurrent Mechanisms in Kidney Function

In a countercurrent mechanism, fluid flows in ___ directions relative to each other.

opposite

p.6
Loop of Henle Structure and Function

The loop of Henle is responsible for a high concentration of ___ in the interstitial fluid.

solutes

p.17
Micturition Reflex and Urinary Bladder Anatomy

As the volume of the urinary bladder decreases, transitional epithelial cells assume their former shape and form a greater number of ___ layers.

cell

p.6
Medullary Concentration Gradient

The concentration of solutes in the medulla increases from ___ mOsm/L to ___ mOsm/L.

300, 1200

p.22
Micturition Reflex and Urinary Bladder Anatomy

As the urinary bladder fills with urine, ___ increases, stimulating stretch receptors.

pressure

p.22
Micturition Reflex and Urinary Bladder Anatomy

Action potentials produced by stretch receptors are carried along ___ nerves to the sacral region.

pelvic

p.11
Renin-Angiotensin-Aldosterone System

Angiotensin II stimulates the adrenal cortex to secrete ___.

aldosterone

p.18
Micturition Reflex and Urinary Bladder Anatomy

The first sign of urinary bladder cancer is often ___ in the urine, known as macrohematuria.

blood

p.14
Atrial Natriuretic Hormone (ANH) Function

The action of ANH increases urine volume while reducing ___ and ___ .

blood volume, blood pressure

p.18
Micturition Reflex and Urinary Bladder Anatomy

In earlier stages of bladder cancer, treatment is more ___ than in later stages.

effective

p.22
Body Fluid Compartments and Regulation

The body’s weight composed of water decreases as the amount of ___ tissue increases.

adipose

p.18
Micturition Reflex and Urinary Bladder Anatomy

Contractions of smooth muscle in the urinary bladder force urine to flow through the ___.

urethra

p.13
Hormonal Regulation of Urine Concentration

The posterior pituitary secretes ___ in response to decreased blood pressure.

ADH

p.12
Hormonal Regulation of Urine Concentration

Antidiuretic hormone (ADH) is secreted by neurons in the ___ pituitary.

posterior

p.13
Hormonal Regulation of Urine Concentration

Baroreceptors monitor blood pressure and detect a significant decrease in ___ pressure.

blood

p.2
Reabsorption Mechanisms in the Kidney

The production of thick, concentrated urine is advantageous to a desert animal because it helps to conserve ___.

water

p.2
Reabsorption Mechanisms in the Kidney

The thick segment of the ascending limb of the loop of Henle is involved in the process of ___ reabsorption.

solute

p.17
Micturition Reflex and Urinary Bladder Anatomy

The triangular portion of the urinary bladder between the openings of the ureters and urethra is called the ___.

trigone

p.17
Micturition Reflex and Urinary Bladder Anatomy

Transitional epithelium allows cells to ___ past one another as the volume of the bladder changes.

slide

p.9
Hormonal Regulation of Urine Concentration

The distal convoluted tubule and collecting duct are permeable to water when under ___ regulation.

hormonal

p.22
Micturition Reflex and Urinary Bladder Anatomy

The micturition reflex is activated by ___ of the urinary bladder wall.

stretch

p.18
Micturition Reflex and Urinary Bladder Anatomy

The 5-year survival rate for urinary bladder cancer, if detected early, is ___%.

77

p.18
Micturition Reflex and Urinary Bladder Anatomy

The most common treatment for early-stage bladder cancer involves introducing a fluid containing live ___-causing bacteria into the bladder.

tuberculosis

p.14
Atrial Natriuretic Hormone (ANH) Function

ANH acts on the kidney to decrease ___ reabsorption.

Na+

p.10
Renin-Angiotensin-Aldosterone System

An increase in blood volume causes blood pressure to ___, while a decrease causes it to go down.

rise

p.16
Micturition Reflex and Urinary Bladder Anatomy

When the urinary bladder reaches a volume of a few hundred mL, its wall is stretched enough to activate a ___ that causes contraction of the bladder.

reflex

p.16
Micturition Reflex and Urinary Bladder Anatomy

Cystitis is an inflammation of the urinary bladder, usually resulting from a ___ infection.

bacterial

p.5
Body Fluid Compartments and Regulation

The kidneys can produce very dilute or very concentrated urine while maintaining extracellular fluid concentration close to ___ mOsm/L.

300

p.11
Renin-Angiotensin-Aldosterone System

Some diuretics inhibit the active transport of Na+ in the ___.

nephron

p.20
Micturition Reflex and Urinary Bladder Anatomy

The micturition reflex is under ___ regulation.

parasympathetic

p.4
Reabsorption Mechanisms in the Kidney

If active transport of Na+ in the thick segment of the loop of Henle were prevented, the concentration of solutes in the medulla would ___.

decrease

p.2
Reabsorption Mechanisms in the Kidney

The desert kangaroo rat produces ___, highly concentrated urine.

thick

p.3
Reabsorption Mechanisms in the Kidney

The active transport of solutes contributes to the kidneys’ ability to conserve ___.

water

p.17
Micturition Reflex and Urinary Bladder Anatomy

The ureters extend from the renal pelvis to the ___ ___ .

urinary bladder

p.23
Body Fluid Compartments and Regulation

The interstitial fluid is the fluid found surrounding the cells of the body and filling the ___ spaces.

extracellular

p.12
Hormonal Regulation of Urine Concentration

A low blood solute concentration ___ ADH secretion.

inhibits

p.12
Hormonal Regulation of Urine Concentration

Inhibition of ADH secretion reduces ___ volume.

urine

p.16
Hormonal Regulation of Urine Concentration

When blood volume is outside the normal range, it causes ___ to be disturbed.

homeostasis

p.16
Hormonal Regulation of Urine Concentration

The control centers respond to changes in blood volume by causing ___ and ___ secretion to decrease.

ADH, aldosterone

p.7
Countercurrent Mechanisms in Kidney Function

In the descending limb of the loop of Henle, water moves across the epithelium by ___ toward the higher solute concentration.

osmosis

p.5
Reabsorption Mechanisms in the Kidney

Water reabsorption occurs through ___ across the wall of the distal convoluted tubule.

osmosis

p.22
Micturition Reflex and Urinary Bladder Anatomy

The external urethral sphincter is normally contracted due to stimulation from the ___ motor nervous system.

somatic

p.21
Micturition Reflex and Urinary Bladder Anatomy

Voluntary initiation of micturition requires an increase in action potentials sent from the ___ to facilitate the micturition reflex.

cerebrum

p.22
Body Fluid Compartments and Regulation

Approximately ___% of the total body weight of an adult female is water.

50

p.22
Body Fluid Compartments and Regulation

Water and ions are distributed in two major compartments: the intracellular fluid compartment and the ___ fluid compartment.

extracellular

p.18
Micturition Reflex and Urinary Bladder Anatomy

The internal urethral sphincter prevents urine leakage from the urinary bladder and contracts to keep ___ from entering the bladder.

semen

p.4
Reabsorption Mechanisms in the Kidney

The thick segment of the loop of Henle is not permeable to ___.

water

p.4
Reabsorption Mechanisms in the Kidney

As filtrate moves through the loop of Henle, it becomes very concentrated toward the ___.

hairpin turn

p.2
Reabsorption Mechanisms in the Kidney

Having loops of Henle that are proportionally ___ than those of other terrestrial animals allows for concentrated urine production.

longer

p.3
Countercurrent Mechanisms in Kidney Function

Cotransport is responsible for moving ___ and ___ with Na+ across the membrane of the ascending limb.

K+, Cl−

p.17
Micturition Reflex and Urinary Bladder Anatomy

The walls of the ureters and urinary bladder are lined with ___ epithelium.

transitional

p.23
Body Fluid Compartments and Regulation

The concentration of protein in the intracellular fluid is ___ than that in the extracellular fluid.

greater

p.23
Body Fluid Compartments and Regulation

The extracellular fluid is divided into multiple subcompartments, including interstitial fluid, plasma, and ___ fluid.

cerebrospinal

p.18
Micturition Reflex and Urinary Bladder Anatomy

In the United States, there are more than ___ new cases of urinary bladder cancer diagnosed each year.

60,000

p.14
Hormonal Regulation of Urine Concentration

ADH is more sensitive to changes in blood osmolarity than to ___ .

blood pressure

p.14
Atrial Natriuretic Hormone (ANH) Function

An increased blood pressure triggers the secretion of ___ from cardiac muscle cells in the right atrium.

Atrial Natriuretic Hormone (ANH)

p.10
Renin-Angiotensin-Aldosterone System

The kidneys help regulate blood pressure by affecting blood ___ through urine production.

volume

p.16
Micturition Reflex and Urinary Bladder Anatomy

The urinary bladder can hold from a few milliliters (mL) to a maximum of about ___ mL of urine.

1000

p.7
Countercurrent Mechanisms in Kidney Function

The vasa recta supply blood to the kidney medulla and remove excess water and solutes without changing the high concentration of solutes in the ___ interstitial fluid.

medullary

p.5
Reabsorption Mechanisms in the Kidney

Ammonia is a toxic by-product of ___ metabolism.

protein

p.21
Micturition Reflex and Urinary Bladder Anatomy

Irritation of the urinary bladder or urethra can initiate the urge to urinate even when the bladder is nearly ___.

empty

p.21
Micturition Reflex and Urinary Bladder Anatomy

A kidney stone can cause discomfort in the lateral abdominal region, which may radiate to the ___ region.

inguinal

p.15
Hormonal Regulation of Urine Concentration

Hormonal regulation plays a crucial role in maintaining ___ in the body.

homeostasis

p.19
Micturition Reflex and Urinary Bladder Anatomy

The urethral sphincter is more clearly detailed for the ___ urethra.

male

p.12
Hormonal Regulation of Urine Concentration

ADH is released when the solute concentration of the blood or interstitial fluid ___ .

increases

p.9
Countercurrent Mechanisms in Kidney Function

The concentration of the filtrate increases to about ___ mOsm/L after reabsorption.

1200

p.9
Loop of Henle Structure and Function

Both the thin and thick segments of the ascending limb of the loop of Henle are impermeable to ___.

water

p.9
Reabsorption Mechanisms in the Kidney

Na+, Cl−, and K+ are symported from the filtrate into the interstitial fluid in the ___ segments.

thick

p.9
Countercurrent Mechanisms in Kidney Function

The solute concentration of the filtrate decreases from 1200 to about ___ mOsm/L.

100

p.6
Medullary Concentration Gradient

The interstitial fluid in the medulla has a very high solute concentration compared to the ___.

cortex

p.9
Hormonal Regulation of Urine Concentration

The kidneys change the concentration of the body fluids by adjusting water ___ and ___.

reabsorption, secretion

p.11
Renin-Angiotensin-Aldosterone System

Angiotensin II increases blood pressure and enhances the sensation of ___ and ___ appetite.

thirst, salt

p.11
Renin-Angiotensin-Aldosterone System

An increase in blood pressure in the afferent arteriole leads to a ___ in renin secretion.

reduction

p.18
Micturition Reflex and Urinary Bladder Anatomy

At least ___% of urinary bladder cancer cases can be attributed to cigarette smoking.

50

p.14
Reabsorption Mechanisms in the Kidney

When Na+ remains in the tubules of the nephron, water moves by osmosis toward the ___ .

Na+

p.10
Renin-Angiotensin-Aldosterone System

When blood volume increases above normal, the kidneys produce a large volume of ___ to lower blood pressure.

urine

p.10
Renin-Angiotensin-Aldosterone System

Diuretics are medications that cause a person to urinate more ___, thereby lowering blood pressure.

frequently

p.10
Renin-Angiotensin-Aldosterone System

Renin is secreted by cells of the juxtaglomerular apparatuses in the kidneys when blood pressure ___ .

decreases

p.21
Micturition Reflex and Urinary Bladder Anatomy

The micturition reflex is an automatic reflex but can be inhibited or stimulated by higher centers in the ___.

brain

p.9
Diabetes Mellitus and Urine Concentration

Around ___% or less of the filtrate remains as urine when the body is conserving water.

1

p.5
Reabsorption Mechanisms in the Kidney

The reabsorption of K + and H + occurs in the ___ convoluted tubule or collecting duct.

distal

p.5
Hormonal Regulation of Urine Concentration

The reabsorption of solutes in the distal convoluted tubule is generally under ___ control.

hormonal

p.22
Micturition Reflex and Urinary Bladder Anatomy

Integration of the micturition reflex occurs in the ___ cord.

spinal

p.11
Renin-Angiotensin-Aldosterone System

Aldosterone increases the reabsorption of ___ and ___ in the distal convoluted tubules.

Na+, Cl-

p.18
Micturition Reflex and Urinary Bladder Anatomy

The procedure used to confirm urinary bladder cancer is called ___ (si-STOS-kuh-pee).

cystoscopy

p.22
Body Fluid Compartments and Regulation

Approximately ___% of the total body weight of an adult male consists of water.

60

p.10
Renin-Angiotensin-Aldosterone System

The renin-angiotensin-aldosterone mechanism is initiated under ___ blood pressure conditions.

low

p.7
Countercurrent Mechanisms in Kidney Function

As filtrate moves through the ascending limb, solutes ___ out of the filtrate, increasing the concentration of the interstitial fluid.

diffuse

p.5
Role of Antidiuretic Hormone (ADH)

The hormone ___ is present for water reabsorption in the distal convoluted tubule.

ADH

p.11
Renin-Angiotensin-Aldosterone System

Aldosterone increases Na+ and water reabsorption in the ___.

kidney

p.21
Micturition Reflex and Urinary Bladder Anatomy

Awareness of the need to urinate occurs because stretch of the urinary bladder stimulates ___ nerve fibers.

sensory

p.18
Micturition Reflex and Urinary Bladder Anatomy

The average treatment time for BCG therapy is about ___ weeks.

6

p.10
Renin-Angiotensin-Aldosterone System

Angiotensinogen is converted to angiotensin I by the enzyme ___ secreted by the kidneys.

renin

p.21
Micturition Reflex and Urinary Bladder Anatomy

A common treatment for kidney stones is ___, an ultrasound technique that pulverizes stones into small particles.

lithotripsy

p.1
Reabsorption Mechanisms in the Kidney

The ascending limb of the loop of Henle is still permeable to ___, which exit the limb.

solutes

p.1
Reabsorption Mechanisms in the Kidney

By the end of the thin segment of the descending limb, the volume of the filtrate has been reduced by another ___%.

15

p.8
Reabsorption Mechanisms in the Kidney

By the time the filtrate reaches the deepest part of the loops of Henle, its volume has been reduced by an additional ___% of the original volume.

15

p.8
Countercurrent Mechanisms in Kidney Function

Much urea returns to the medulla from the collecting duct, rather than exiting with the ___ .

urine

p.1
Reabsorption Mechanisms in the Kidney

The descending limb of the loop of Henle is highly permeable to ___.

water

p.1
Diabetes Mellitus and Urine Concentration

Diabetes mellitus differs from that of a healthy person in terms of ___ concentration in urine.

urine

p.8
Countercurrent Mechanisms in Kidney Function

Urea is responsible for a substantial part of the high solute concentration in the kidney ___.

medulla

p.8
Countercurrent Mechanisms in Kidney Function

Blood pressure in the vasa recta is very ___ and blood flow rate is extremely slow.

low

p.8
Countercurrent Mechanisms in Kidney Function

As the filtrate enters the descending limbs of the loops of Henle, the surrounding interstitial fluid has a progressively greater ___.

concentration

p.8
Countercurrent Mechanisms in Kidney Function

The vasa recta are ___ to both water and solutes.

permeable

p.8
Reabsorption Mechanisms in the Kidney

In the average person, about ___ L of filtrate enter the proximal convoluted tubules daily.

180

p.1
Reabsorption Mechanisms in the Kidney

The descending limb of the loop of Henle is primarily made up of ___ epithelial tissue.

simple squamous

p.8
Reabsorption Mechanisms in the Kidney

Cells of the proximal convoluted tubule reabsorb approximately ___% of the filtrate.

65

p.8
Countercurrent Mechanisms in Kidney Function

As blood flows toward the medulla, water moves out of the ___ recta.

vasa

p.1
Reabsorption Mechanisms in the Kidney

The concentration of the filtrate at the end of the descending limb reaches ___ mOsm/L.

1200

p.8
Countercurrent Mechanisms in Kidney Function

Sodium ions and other solutes are actively transported into the ___ fluid of the medulla.

interstitial

p.1
Reabsorption Mechanisms in the Kidney

In the ascending limb of the loop of Henle, the epithelium becomes impermeable to ___.

water

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